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Defense-peptides against mycobacteria
(2005-09-07)
Several members of the genus Mycobacterium can cause serious infections
in both man and animal. One of the world's most serious infectious
diseases, tuberculosis, is caused by the pathogen Mycobacterium
tuberculosis. ...
Opioids and regulation of breathing
(2004-10-29)
A most important challenge even in modern medicine is effective treatment of pain. Respiratory depression is the most feared side effect of analgesic treatment in the clinical situation. The serious effect of opioid induced ...
Modulation of tumor sensitivity to effector mechanisms of cytotoxic lymphocytes
(2004-11-12)
Today, ample evidence demonstrates a clear role for the immune system in the battle against cancer. However, the relatively high rate of mutation and proliferation of tumor cells, in combination with the selective pressure ...
Identification, cloning and characterization of the p53 induced gene human Wig-1
(2004-11-26)
levels
of the two Wig-1 protein species vary in human tumor cell lines. We also
demonstrate that the two forms are generated by translation initiation
from different AUG initiation codons. Wig-1 was induced by gamma
irradiation and 5fluorouracil (5-FU...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9.5...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Coronary artery bypass surgery without extracorporeal circulation
(2006-03-10)
Introduction: Coronary artery bypass surgery with extracorporeal circulation is associated with a systemic inflammatory response syndrome that contributes to morbidity and mortality. Aortic cross clamping and cardioplegic ...
Aspects on the psychopharmacology of cholecystokinin
(2005-05-20)
This thesis includes studies of the effect of mild stress on brain cholecystokinin (CCK), anatomy of markers for CCK-ergic transmission in the brain and the systemic effect of CCK receptor stimulation in a clinical test ...
Kinetics of HIV-1 drug resistance mutations in vivo
(2006-03-10)
Antiretroviral therapy (ARV) exert a selective pressure on HIV-1 and may select viral drug resistant strains which have competitive advantage in the presence of the drug. Knowledge about the appearance and disappearance ...
Inflammation and neurodegeneration in mouse nervous system : experimental application
(2006-01-26)
myelin protein PO peptide 180-199. CCR5-/- mice showed a similar clinical course and severity of EAN as well as the profile of infiltrating inflammatory cells in cauda equina (CE) of mice, and the same levels of spleen mononuclear cell (MNC) response...