Search
Now showing items 1-10 of 103
Genetic susceptibility to breast and endometrial cancer
(2004-09-10)
preparations.
We found that a COMT allele that confers high enzyme activity (c.324/474A>G G) was associated with increased risk for lobular breast cancer, but not with breast cancer risk overall. The CYP1B1 variants, c.355G>T, c.4326C>G, and c.4390A>G, were...
Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol lowering drugs in Alzheimer's disease
(2006-05-12)
responses were found in rat primary astrocytes, whereas neither alpha2 nor alpha3 could be detected. Elevation in the levels of alpha7, alpha4, beta2 mRNAs and proteins was observed in astrocytes exposed to 0.1 - 100 nM Abeta1-42, which is different from...
Brain cholesterol metabolism : a study of mouse and man
(2005-09-16)
The brain is the most cholesterol rich organ in the body and contains
about one quarter of the body's total cholesterol. How this cholesterol
and its metabolism affects the complex brain under normal and
pathological ...
Interactions between mouse CNS cells : microglia and neural precursor cells
(2004-11-05)
The mammalian central nervous system (CNS) contains a variety of cells,
all specialized to perform different functions. Most numerous are the
three types of glia cells, whose basic role is to support the signaling
units ...
Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease
(2005-01-07)
Alzheimer’s disease (AD) is the most frequent type of dementia and is characterized neuropathologically by deposition of plaques containing beta-amyloid (Abeta) and by neurofibrillary tangles, of which the main component ...
Native protein mass spectrometry of nuclear receptor-ligand and enzyme-substrate complexes
(2004-11-05)
medium resolution, amass error of better than 0.2 Da was obtained. This is sufficient to identify the degree of unsaturation or cyclisation if the compound class, for instance fatty acid, is known.
The methodology developed for investigation of protein...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
periodontal disease and bad breath demonstrated a higher percentage of teeth with pockets =5 mm than did individuals without bad breath (p<0.001). Moreover subjects with foetor ex ore showed significantly higher levels of plaque and calculus values than did...
Transoesophageal and transthoracic recordings of mitral annulus motion
(2006-02-03)
-RVm) were used for recordings of RVm and according to Fisher's exact test both methods can be used to detect diastolic dysfunction but velocities obtained by TD-RVm was 29.7% (p<0.0001) higher than M-RVm. Sensitivity and specificity for M-RVm to correctly...
Pain, its assessment and treatment using sensory stimulation techniques : methodological considerations
(2006-05-12)
Pain is a worldwide clinical problem that causes great suffering for the individual and costs for society. The assessment and evaluation of perceived pain is necessary for diagnosis, choice of treatment, and for the ...
Hairdressers : hand eczema, hair dyes and hand protection
(2006-10-06)
Hand eczema is a well-known problem in occupations that involve largely manual work, in combination with long periods of wet exposure and skin contact with chemicals. Hairdressing involves dermal exposure to a number of ...