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The impact of protein modification on immunogenicity and arthritogenicity
(2005-09-09)
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting about 1% of the Western world population. There are several theories regarding the etiopathogenesis.
The aim of this thesis was to study, ...
The in-vitro and in-vivo metabolism of the oral anticoagulant phenprocoumon as influenced by genetic polymorphisms of cytochrome P4502C9
(2004-11-16)
combinations of CYP2C9*1, 2C9*2 and 2C9*3. Overall, the plasma clearance of S-PPC was moderately reduced in CYP2C9 variant allele carriers, while RPPC clearance was essentially unaffected. However, the metabolite formation clearances were impaired in a gene...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Improving medical abortion : using mifepristone in combination with a prostaglandin analogue
(2005-09-16)
Background: Induced abortion is still a major health problem in the world and the most frequently performed intervention in Obstetrics and Gynaecology with an estimated total of 46 millions worldwide each year. Medical ...
Arthritogenic and immunogenic properties of modified autoantigens
(2005-03-22)
Rheumatoid arthritis is a chronic inflammatory joint disorder with autoimmune features in which both genetic and environmental factors are potential contributors to the arthritogenic process. In this thesis work we aimed ...
Patellar tendinopathy : on evaluation methods and rehabilitation techniques
(2006-10-27)
Background: Patellar tendinopathy is an increasingly common overuse and degenerative injury for recreational and elite athletes. The management of this injury is often difficult and frustrating and the treatment may take ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9...
Tobacco smoking and vertical periodontal bone loss
(2005-05-18)
Cigarette smoking is associated with increased prevalence and severity of destructive periodontal disease in terms of periodontal pocketing, periodontal bone loss, and tooth loss. The smoking destructive effect on periodontal ...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
model. We found no association between magnetic field exposure and childhood leukaemia overall. However, elevated risk estimates were found in subgroup analyses of acute lymphoblastic leukaemia in the 5-9 year age group. Random variation is a likely...