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Biological aspects of synovial fluid mediated aseptic prosthesis loosening
(2005-08-26)
Aseptic prosthesis loosening is the most common reason for late failure of total hip arthroplasties. Resorption of the peri-prosthetic bone, resulting in a loose prosthesis is characteristic for aseptic loosening. The ...
Antiplasmin the main plasmin inhibitor in blood plasma : studies on structure-function relationships
(2005-04-06)
Antiplasmin is an important regulator of the fibrinolytic system. It
inactivates plasmin very rapidly. The reaction between plasmin and
antiplasmin occurs in several steps: first a lysine-binding site in
plasmin interacts ...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...
Orthology and protein domain architecture evolution
(2006-05-22)
A major factor behind protein evolution is the ability of proteins to evolve new domain architectures that encode new functions. Protein domains are widely considered to constitute the "atoms" of protein chains, acting as ...
Patient-orientated aspects of the postoperative course after hernia surgery
(2006-09-01)
Operations for inguinal hernia are one of the most common surgical procedures performed. With the development of mesh techniques, recurrence rates have improved radically and patient-orientated endpoints have evolved as ...
Structure determination, thermal stability and catalytic mechanism of hyperthermostable isocitrate dehydrogenases
(2006-05-02)
In this thesis, studies on the enzyme isocitrate dehydrogenase (IDH) from the hyperthermophiles Aeropyrum pernix (ApIDH), Thermotoga maritima (TmIDH), Archaeoglobus fulgidus (AfIDH) and Pyrococcus furiosus (PfIDH) are ...
Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts
(2005-11-11)
Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes collectively responsible for the metabolism of extra cellular matrix components. Disturbance of the physiological balance between MMPs and their endogenous ...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...
Viridans group streptococci septicaemia and endocarditis : molecular diagnostics, antibiotic susceptibility and cinical aspects
(2005-04-27)
Viridans group streptococci (VGS) are inhabitants in the oral cavity and in the gastrointestinal tract. They cause severe infections, they are responsible for up to 39 % of the cases of septicaemia in neutropenic patients ...
Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods
(2006-03-17)
Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the ...