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Mechanisms of adaptive mutations in bacteria
(2005-10-07)
Bacteria have the ability to adapt to various challenging environments. The rate, extent and consequences of bacterial adaptation depend on both microbial and environmental factors. This thesis analyses some of the mechanisms ...
Ghrelin action on gastrointestinal functions and appetite in rat and man
(2006-04-21)
To study the effect of ghrelin on the contractility of smooth muscle strips in vitro as well as the effects on fasting small bowel motility and acid secretion in vivo in rats and gastric emptying in rats and humans. To ...
Clinical and immunological aspects of human parvovirus B19 infection
(2005-01-28)
Human parvovirus B19 (B19) causes erythema infectiosum, a limited disease of childhood also known as the fifth disease or slapped cheek syndrome, referring to the characteristic facial rash. It normally infects through the ...
PET studies of the serotonin transporter in the human brain
(2006-10-27)
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination...
Ethyl glucuronide : a new biochemical marker for acute alcohol intake : studies on possible causes for false-negative or false-positive results
(2006-02-17)
, such as ethanol, 5-hydroxytryptophol(5HTOL), ethyl glucuronide (EtG) and ethyl sulfate (EtS), and 2) tests that are able to detect chronic heavy drinking, or indicate body organ or tissue damage caused by long-term exposure to alcohol, such as carbohydrate...
Physical fitness and overweight in Swedish youths
(2005-03-22)
in 10-year-old girls and the lowest (17.5%, 95% CI: 13.6 to 22.2) in 16-year-old girls. The prevalence in 2001 was nearly 2.5 times higher, compared to the 1987-sample. Girls attending schools in smaller towns or on the countryside had a nearly two...
The human skeletal muscle in vivo : the use of microdialysis to study glucose metabolism and insulin resistance
(2004-11-26)
The aim of this thesis was to further develop the microdialysis technique for studies of glucose metabolism and insulin resistance in human skeletal muscle in vivo and to use this technique to explore the effect of exercise ...
Quality of care and quality of life in coronary artery disease
(2005-02-09)
.3% from 4.2 (CI 4.0-4.5) to 3.7 (CI 3.4-4.0) mmol/l in the intervention group and was 0.5 (CI 0.1-0.9) mmol/l lower (effect size 0.56) in the intervention group as compared to the control group (p < 0.05) after two years. We found no change in the control...
Lactobacilli expressing antibody fragments against pathogens
(2006-11-03)
for therapy against gastrointestinal infections. We first analysed the possibility of expressing functional model VHH fragments under the control of an inducible promoter. Two VHH fragments, VHH2 (directed against the capsid of the phage) and VHH5 (directed...
Heart failure : aspects on treatment and prognosis
(2006-05-02)
The aim of this thesis was to describe aspects on treatment and prognosis in heart failure. In paper I, we studied two hundred and seventy-nine hospitalised heart failure patients, and related clinical and demograhic data ...