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Neocortical layer 2/3 microcircuits
(2004-10-13)
and excitatory connections onto layer 2/3 pyramidal cells, in neocortical microcircuits. Two types of neocortical microcircuit were studied; fast-spiking non-accommodating interneuron (FSN)-pyramidal cell, and pyramidalpyramidal cell microcircuits...
Xenobiotics-induced phosphorylations of MDM2
(2006-11-24)
The aim of the present study was to characterize the Mdm2 and p53 responses induced by DNA damaging xenobiotics and how these responses can be modified by non-genotoxic xenobiotics. During control conditions cellular levels of p53 are low. The level...
Functional studies on the interaction of immunoglobulins with HIV-2 envelope
(2005-09-16)
Infection with HIV-2 has a much more limited geographic distribution than HIV-1, being less readily transmitted and is generally less pathogenic. The role of immunoglobulins in defence against pathogens in different body compartments is known, where...
Epstein-Barr virus nuclear antigen 1, Oct and Groucho/TLE in control of promoter regulation
(2005-11-04)
The human herpes virus Epstein-Barr virus (EBV) is carried by
approximately 95% of the adult population. It can form a lifelong latent
infection in the B-cells by avoiding our immune system. A latent EBV
infection is ...
Novel methods for the identification of cellular S-glutathionylated proteins and sites of glutathionedependent modification using affinity chromatography and proteomic analyses
(2005-02-21)
-glutathionylated proteins under non-reducing conditions, in an attempt to avoid the cumbersome 2-D gel electrophoresis step and at the same time identify the sites of S-glutathionylation by tandem mass spectrometry. The glutathionylation sites of gamma-actin, heat...
Regulation of carbohydrate metabolism in skeletal muscle during and after contraction
(2006-11-03)
during exercise will lead to new strategies for treating or preventing increasingly prevalent diseases like type 2 diabetes. The aim of this thesis was to study the regulation of carbohydrate metabolism in skeletal muscle during and after contraction...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...
Diabetes, physical activity and endometrial cancer
(2006-11-22)
cancer, we identified 16 studies (3 cohort and 13 case-control studies), and found that diabetes was statistically significantly associated with an increased risk of endometrial cancer incidence, (summary RR = 2.10 95% CI= 1.75-2.53). Analysis of 2...
Apoptosis in the myelodysplastic syndromes : protective effect of G-CSF
(2005-09-23)
Increased apoptosis of hematopoietic progenitor cells is a hallmark for
the myelodysplastic syndromes (MDS), and one of the main reasons for the
ineffective hematopoiesis and subsequent cytopenia characteristic for ...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...