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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Motor function and cognition : aspects on gait and balance
(2005-11-25)
Introduction: Cognitive dysfunction and dementia are linked to physical
disability and are the major cause of dependency and institutionalization
in the elderly. Physical therapists deal with disability yet little
clinical ...
Endometrial carcinoma : prognostic factors and protein expression profiling
(2004-09-24)
Endometrial carcinoma is the most common gynaecological cancer in the
western world. It is usually diagnosed at an early stage since it
presents with irregular vaginal bleeding when the tumour is still limited
to the ...
Molecular regulation of microsomal triglyceride transfer protein gene, MTP : functional genetic studies in relation to cardiovascular disease
(2004-11-26)
The microsomal triglyceride transfer protein, MTP, is expressed mainly in
the liver, intestine and in the heart. It is crucial for the assembly and
secretion of apob-containing lipoproteins, chylomicrons in the intestine
and ...
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis in vivo. The following...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities.
In the first part of this thesis we could establish and confirm ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-chloroacrylonitrile yielded, after expulsion of HCN by refluxing in ethanol, 1-benzyl-4,5,6,7-tetrahydroindole. Formylation and benzylimine formation followed by treatment with TosMIC furnished the desired 2-imidazolyltetrahydroindole....
Physical fitness and overweight in Swedish youths
(2005-03-22)
obese. The total prevalence accordingly being 20.1% (95% CI: 18.3% to 22.0%). This sample proved to be heterogeneous concerning overweight status. When obesity and overweight were combined the highest prevalence (26.6%, 95% CI: 21.2 to 32.7) was found...
Incidence and prognosis of differentiated thyroid cancer in Sweden
(2006-01-06)
with distant metastasis a 7-fold higher risk of death compared with those with no metastases. Non-surgically treated patients had a worsened prognosis. Incomplete surgical excision was associated with higher mortality, particularly among patients in stage I...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and immunodeficiency, only...