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Leukemia chemotherapy : experimental studies on pharmacological optimisation
(2004-11-26)
Our main goal has been to identify new means to improve chemotherapy of
acute leukaemia:
1. By using low-density lipoprotein (LDL) as a drug carrier to increase
the selectivity of antileukemic drugs, based on high LDL ...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
Inflammatory status in adolescents : the impact of health determinants such as overweight and fitness
(2006-03-07)
Overweight prevalences are rising among youth and the prevention of associated chronic diseases is priority concern in public health. Inflammatory processes are involved in the pathogenesis of cardiovascular diseases and ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available ...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Local and systemic inflammatory mediators and their relation to pressure-pain threshold and pain of the temporomandibular joint
(2006-11-17)
The first aim of this investigation was to investigate the validity of TMJ pressure-pain threshold for assessment of pain conditions of inflammatory nature in the TMJ. Pressure-pain threshold was recorded from the palpable ...
Translational studies of drug-induced tumor cell death
(2006-09-29)
It is essential to understand the mechanisms of action of anticancer drugs in order to obtain good treatment results. I have in the present thesis studied clinically used anticancer agents as well as other agents that ...
Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
(2005-03-25)
The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs ...
The health and working conditions of female immigrants in Sweden
(2006-09-01)
the health of immigrants in relation to unemployment status and sick leave absences from a gender perspective. Both qualitative and quantitative methods were used for data collection. The third study was cross-sectional in design and consisted of 2,429 native...
Gastroesophageal reflux disease in adults : the Kalixanda study : a population-based endoscopic study
(2006-12-21)
Gastroesophageal reflux disease (GERD) is a common burden on health care
resources in the Western world and deteriorates the health-related
quality of life of those affected, but its manifestations in the general
population ...