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Resistance to antiviral drugs in HIV and HBV
(2005-02-18)
Development of resistance to antiviral drugs is a major problem in treatment of several viral infections including human immunodeficiency type 1 (HIV-1) and hepatitis B virus (HBV). Resistance may be the primary reason for ...
Physical capacity in individuals with cerebral palsy : problems, needs and resources, with special emphasis on locomotion
(2005-09-09)
Many individuals with cerebral palsy (CP) have difficulties in walking independently because of impaired postural control, abnormal tone and pathological muscular coordination. Walkers are often a prerequisite and are often ...
Paediatric nursing and parenthood : studies of early discharge of preterm infants, mothers’ satisfaction with CHC (child health clinic) care, and risk factors for parenting stress
(2005-05-13)
vaccinations was insufficient. Mothers with depressive symptoms at 2 months as well as 1 year after the birth were least satisfied. The study of risk factors for parenting stress included 2,424 women. Risk factors identified during pregnancy were unemployment...
The in-vitro and in-vivo metabolism of the oral anticoagulant phenprocoumon as influenced by genetic polymorphisms of cytochrome P4502C9
(2004-11-16)
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In Study 1, CYP2C9 and CYP3A4 were identified as major catalysts of S- and R-PPC hydroxylation in vitro by kinetic, correlation and inhibition studies using CYP-specific chemical and immunological inhibitors. Overall, CYP2C9 was little more important than...
Synthesis and evaluation of new PET radioloigands for imaging central norepinephrine transporters
(2006-04-28)
of the most potent and selective NET inhibitors reported to date were prepared and labeled with carbon- 11 (t1/2 20.4 min) or fluorine- 18 (t1/2 109.8 min). Some improvements were also made with regards to the labelling of aryl fluoromethyl ethers and sulfides...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
Chromatin structure and histone modifications in gene regulation
(2006-11-24)
In the living cell, DNA is densely packed into a chromatin structure constituting nucleosomal arrays. One nucleosome core particle includes a disc shaped protein octamer consisting of pairs of histones H2A, H2B, H3 and H4. 146 bp of DNA is wrapped...
On neck load among helicopter pilots : effects of head worn equipment, whole body vibration and neck position
(2005-09-13)
increased by about 0.5-1 % MVE as a function of vibration at frequencies around 4-5 Hz, with the higher levels when the neck was flexed. Muscle activity was also affected by vibration magnitude, where lower-neck-muscle and trapezius activity increased...
Genetic modification of human natural killer cells and possible applications thereof
(2006-08-25)
Natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2) for their survival and for their cytotoxicity against tumor cells. Currently, for in vitro expansion of NK cells from peripheral blood mononuclear ...
Advanced radiological imaging in patients treated with Extracorporeal Memebrane Oxygenation
(2006-11-17)
Extracorporeal membrane oxygenation (ECMO) is the use of a modified heart-lung machine to support life during severe acute cardiac and/or respiratory failure. Patients on ECMO are at high risk for complications due to the ...