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Host control of intracellular bacterial infections
(2004-11-19)
In this thesis various immune mechanisms regulating control of infections with the intracellular bacteria Listeria monocytogenes and Chlamydia pneumoniae have been studied. These bacteria infect macrophages in which they ...
Studies of hepatitis C virus envelope proteins : interaction with host cells and as targets for the humoral response
(2004-11-25)
Hepatitis C virus (HCV) is a major cause of chronic hepatitis infection
worldwide. It leads to chronic infection in over 80% in infected patients
and may result in liver cirrhosis, hepatocellular carcinoma and
autoimmune ...
Unstimulated human whole saliva flow rate in relation to hyposalivation and dental caries
(2005-04-08)
Introduction: Salivary secretion is influenced by a large number of factors, including the circadian rhythm, making the detection of reduced salivary flow (hyposalivation) difficult. This is important since severely reduced ...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
)] and 841 woman [mean age = 35.7 years (±2.9 SD)] who participated in an epidemiological study of periodontal health that was started in 1985, 2.4 % were found to exhibit foetor ex ore and 1 % were diagnosed as having halitophobia. Subjects with both...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Cellular and molecular mechanisms in abdominal aortic aneurysm growth and rapture
(2005-11-11)
-degrading proteases in the AAA wall. Gene arrays and quantitative real-time PCR showed that matrix metalloproteinase (MMP)-1, -7, -9 and -12 mRNA expressions were upregulated in the thrombus-free wall compared with the thrombus-covered wall. Immunohistochemistry...
The impact of age and gender with respect to general joint laxity, shoulder joint laxity and rotation : a study of 9, 12 and 15 year old students
(2005-03-25)
selected schools participated in this Swedish nation-wide research study ("The School project 2001") with a total of 1846 students aged 9-15 included. Data concerning these subjects are reported in study I-III. An additional study group of 120 competitive...