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Effect of estrogen on longitudinal bone growth
(2006-04-14)
Longitudinal bone growth occurs at the growth plate, a thin layer of cartilage between the epiphysis and the metaphysis of long bones. In the growth plate resting chondrocytes proliferate, differentiate into a hypertrophic ...
Palatal plate therapy in children with Down syndrome : a longitudinal study of effects on oral motor function
(2005-09-16)
The aim of this thesis was to investigate the effect of palatal plate therapy on the oral motor function children with Down syndrome (DS) during 4 years by comparing the baseline values of the treatment group with those of a control group (CG...
Nutritional status and cognitive function in frail elderly subjects
(2004-08-13)
attended 12-hour nutritional education program. The care personnel answered a questionnaire before and after the education that reflected their knowledge and attitudes about nutrition in elderly (I, II). Oral supplements (410 kcal/1720 kJ) were given daily...
The complex genetics of experimental autoimmune neuroinflammation
(2004-11-15)
-EAE on rat chromosomes 4, 10 and 12.
We established congenic lines, DA.PVG-Eae20, DA.ACI-Eae18 and BN.DA-Eae5, encompassing the previously identified EAE-susceptibility regions on rat chromosomes 4, 10 and 12, respectively. The inbred DA rat strain...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Catalytic mechanisms and evolution of leukotriene A4 hydrolyse
(2006-11-10)
of chemical mediators, which by different means control, maintain and resolve the process. One group of such mediators is the leukotrienes, among which LTB4 is found. LTB4 has several immunomodulating properties and mainly acts by recruiting leukocytes...
Chromatin structure and histone modifications in gene regulation
(2006-11-24)
In the living cell, DNA is densely packed into a chromatin structure constituting nucleosomal arrays. One nucleosome core particle includes a disc shaped protein octamer consisting of pairs of histones H2A, H2B, H3 and H4. 146 bp of DNA is wrapped...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
and GLP-1 on gastric emptying, metabolic control and appetite after intake of a mixed meal in man. In addition, I (3) studied the effects of ghrelin on smooth muscle contractility in rat and (4) its effect on gastric emptying in humans after intake of a...
Inflammatory status in adolescents : the impact of health determinants such as overweight and fitness
(2006-03-07)
status. Studied parameters were: detailed anthropometry, fitness and for the evaluation of inflammatory status, serum acute phase proteins (C-reactive protein, ceruloplasmin and complement factors C3 and C4), as well as in vitro production of interleukin...