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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Computational prediction of antisense oligonucleotides and siRNAs
(2005-09-02)
Search to target 31 Rat genes, 19 (30%) had a silencing activity of 90% or higher and 3 3 (52%) silenced to a level of 70% or more. For 25 of the 31 genes siSearch was successful in predicting siRNAs that silence the gene by more than 80%. The prediction methods...
Catalytic mechanisms and evolution of leukotriene A4 hydrolyse
(2006-11-10)
of peptide hydrolysis, Tyr-383 together with the zinc ion function as a site for oxyanion stabilization of the reaction intermediate. The general base Glu-296, not only facilitates the nucleophilic attack by the hydrolytic water, but also functions as a...
The insulin-like growth factor system : effects of circulating proteases
(2005-08-18)
factors. In scrum most IGF circulate in a ternary complex with IGF-binding protein-3 (IGFBP-3) and the acid labile subunit (ALS). The affinity between IGF and IGFBP-3 exceeds that between IGF and the type 1 IGF receptor demonstrating that most...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-component reactions between isatin, alpha-amino acid derivatives, and suitable dipolarophiles. Condensation between isatin and an alpha-amino acid yielded a cyclic intermediate, an oxazolidinone, which decarboxylate to give a 1,3-dipolar species, an azomethine ylide...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Studies of glucocorticoid receptor interacting proteins
(2005-05-06)
complexes. Using Western Blotting we have identified 14-3-3, Raf-1 and NF-kappaB and IkappaBalpha as GR co-purifying proteins in the rat liver cytosol. We identified Flt3 among the GR co-purifying proteins using Edman based N-terminal sequencing. Flt3...
Novel insulin-like growth factor-binding protein proteases : detection and characterization
(2006-10-07)
the availability of IGFs (IGF-I and IGF-II) to their receptors. In the circulation IGFs and IGFBP-3 or IGFBP-5 can bind an acid-labile subunit (ALS) to form a high molecular mass complex, which constitutes a circulating reservoir of IGFs. Post...
Development of a vaccine against strangles
(2005-09-16)
Strangles is an acute upper respiratory tract disease in the horse, which is characterized by purulent pharyngitis and lymphadenitis. It is caused by Streptococcus equi subsp. equi. The severe suffering and economical ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...