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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Leukemia chemotherapy : experimental studies on pharmacological optimisation
(2004-11-26)
Our main goal has been to identify new means to improve chemotherapy of
acute leukaemia:
1. By using low-density lipoprotein (LDL) as a drug carrier to increase
the selectivity of antileukemic drugs, based on high LDL ...
Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease
(2005-01-07)
Alzheimer’s disease (AD) is the most frequent type of dementia and is characterized neuropathologically by deposition of plaques containing beta-amyloid (Abeta) and by neurofibrillary tangles, of which the main component ...
The study of sensory cilia development in Caenorhabditis elegans
(2008-01-04)
Cilia and flagella are widespread eukaryotic subcellular components
that are conserved from green algae to mammals. In different organisms
they function in cell motility, movement of extracellular fluids and
sensory ...
Transoesophageal and transthoracic recordings of mitral annulus motion
(2006-02-03)
Maximal systolic and diastolic velocities recorded from four sites of the mitral annulus motion (MAM) reflect left ventricular (LV) performance. This thesis focus on factors influencing M-mode derived velocities in healthy ...
Familial risks for cancer with reference to lung cancer
(2004-10-15)
between offspring and parents were 1.98 for adenocarcinoma (offspring) and small cell/large cell carcinoma (parents), 2.66 for squamous cell carcinoma and small/large cell carcinoma (offspring/parents), 3.54 for small cell carcinoma and squamous cell...
Posterior capsule opacification and postoperative endophthalmitis following cataract surgery : predictive and protective factors
(2005-04-01)
Modem cataract surgery with implantation of an intraocular lens (IOL) is an increasingly safe and successful procedure, though complications still occur. This thesis addresses the most common complication, posterior capsule ...
Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes
(2004-10-29)
The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and ...
HIV-1 phenotype and genetic variation in vertical transmission
(2006-01-20)
, and was hence not the directly contributing cause of AIDS. In the second study, we wanted to examine the phenotypes in mother-child pairs. A statistically significant link was found between the presence of X4 in the mothers and the development of X4...
Regulation of gene transcription by the thyroid hormone receptors
(2006-05-26)
transcription of the Necdin promoter and that TH repressed this activation. We further showed that TR bound as a heterodimer with Retinoic-X-receptor (RXR) to the Necdin nTRE sequence and that RXR and the nuclear receptor corepressor (NCoR) enhanced the TR...