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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Defense-peptides against mycobacteria
(2005-09-07)
. The postulated membrane-docking part, helix
2-loop-helix 3, of NK-lysin was found to retain or even improve their
antimicrobial activity compared to their parent molecules. It was also
demonstrated that the shorter peptides maintained their activity against
M...
Motion analysis of the knee : kinematic artifacts, EMG normalisation and joint forces
(2005-04-25)
joint forces, and insufficient measurement accuracy of 3D knee joint kinematics.
The aim of this thesis is to address some of these issues by: (1) evaluating techniques of electromyography (EMG) analysis with ACL patients; (2) investigating...
Algorithms for building and evaluating multiple sequence alignments
(2006-09-05)
The alignment of biological sequences is crucial for the transfer of annotation from model organisms to humans. Pairwise alignment of sequences can reveal homology while multiple alignments are used to characterize protein ...
Organohalogen environmental pollutants in Baltic fish : chemical characterization and toxicological evaluation with a focus on bone disturbances
(2005-10-28)
, corresponding to human intake of 1.6, 8.2 or 34.4 kg fish /week resulted in general toxic effects that could be described as minimal, even at the high dose level. The spectrum of toxic effects was similar to low-dose effects of exposure to dioxinlike pollutants...
On lumbar spinal stenosis and disc herniation surgery
(2005-04-01)
. The mortality rate declined despite ageing spinal stenosis patients. The length of stay after surgery was reduced to half. Patients operated on for spinal stenosis and disc herniation have a risk of being reoperated after one and ten years of 2-3 %, and 10...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
)] and 841 woman [mean age = 35.7 years (±2.9 SD)] who participated in an epidemiological study of periodontal health that was started in 1985, 2.4 % were found to exhibit foetor ex ore and 1 % were diagnosed as having halitophobia. Subjects with both...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and ...
Viridans group streptococci septicaemia and endocarditis : molecular diagnostics, antibiotic susceptibility and cinical aspects
(2005-04-27)
Viridans group streptococci (VGS) are inhabitants in the oral cavity and in the gastrointestinal tract. They cause severe infections, they are responsible for up to 39 % of the cases of septicaemia in neutropenic patients ...