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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
plaques, where it colocalized with macrophages, endothelial cells, and smooth muscle cells (SMC). Human coronary artery SMC exposed to either the LTB4 Or the BLT1 partial agonist U75302 exhibited increase of whole-cell ion currents indicating...
Regulation of tartrate-resistant purple acid phosphatase by proteolytic processing in rat
(2005-02-25)
inhibitory interactions to active site residues affecting the Fe2+. Conversion of Ser1 45 or Asp 146 into Ala, which should eliminate the putative interaction of the side chains with the active site residues Asn91 or His92, resulted in increased enzyme...
Cellular immune responses against human parvovirus B19 infection
(2006-04-14)
The role of cellular immune responses in the control of Parvovirus B19 (B19) infection has not previously been investigated. B19 does not normally cause severe clinical problems but complications may arise in immunosuppressed ...
Biophysical studies on aggregation processes and amyloid fibrils with focus on Alzheimer's disease
(2004-08-13)
Alzheimer's disease (AD) is a fatal neurodegenerative disease, and is the most common form of dementia, affecting 1-2% of the population in industrialized countries. It is believed that intermediate species formed during ...
Clinical, immunological and olfactory aspects of sinusitis and nasal polyposis : with special reference to patients with cystic fibrosis
(2004-11-26)
The otorhinolaryngological approach to the problem concerning
rhinosinusitis and nasal polyposis in the recessive genetic disorder of
cystic fibrosis (CF) has been developed based on data from international
studies. ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
-carboxaldehyde and 1,4-diacetyl-2,5-piperazinedione ill the presence of caesium carbonate. Several analogues of dipodazine, together with a few barettin analogues have been prepared and tested for activity ill antifouling assays, results and relevance of which...
Viridans group streptococci septicaemia and endocarditis : molecular diagnostics, antibiotic susceptibility and cinical aspects
(2005-04-27)
was found in oral swabs from haematological patients where 25% of the VGS isolates were resistant to penicillin (MIC ≥ 4.0 μg/ml), which was higher that we had expected. This is an important observation because the oral cavity has been described as a genetic...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
is in strong linkage with -318C/T and is more frequently present in MG patients with thymoma. MG patients carrying -318C showed significantly decreased expression of CTLA-4 mRNA in non-stimulated cells. In the present study, the relationship of the expression...
In vivo protein synthesis determinations in human immune cells
(2005-02-18)
of healthy volunteers. The isolated T lymphocytes responded with a 60% decrease of the protein synthesis rate from 9.4 ± 1.2 %/24 h to 3.8 ± 2.4 %/24 h, whereas the whole population of leukocytes showed an increase by 43% from 3.2 ± 1.2 %/24 h to 4.4 ± 1...