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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Laparoscopic and open surgery for colon cancer : studies on costs and health related quality of life
(2006-05-19)
patients underwent surgery during the inclusion period of the trial. When comparing patients included in the COLOR trial (n=391) with eligible patients that were not included ("missed inclusions", n=335), no difference was found on age, gender, body mass...
Modulation of immune responses in experimental autoimmune encephalomyelitis
(2005-04-13)
The aim of this thesis work has been to elucidate mechanisms for modulation of the immune response in experimental autoimmune encephalomyelitis (EAE), the animal model for the human disease multiple sclerosis (MS).
MS ...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...
Regulation of gene transcription by the thyroid hormone receptors
(2006-05-26)
Thyroid hormone (TH) has important effects on postnatal development as well as on adult metabolic homeostasis. TH meditates its effects through different isoforms of the thyroid hormone receptors (TRs) encoded by the TRalpha ...
Studies of glucocorticoid receptor interacting proteins
(2005-05-06)
complexes. Using Western Blotting we have identified 14-3-3, Raf-1 and NF-kappaB and IkappaBalpha as GR co-purifying proteins in the rat liver cytosol. We identified Flt3 among the GR co-purifying proteins using Edman based N-terminal sequencing. Flt3...
Novel insulin-like growth factor-binding protein proteases : detection and characterization
(2006-10-07)
the availability of IGFs (IGF-I and IGF-II) to their receptors. In the circulation IGFs and IGFBP-3 or IGFBP-5 can bind an acid-labile subunit (ALS) to form a high molecular mass complex, which constitutes a circulating reservoir of IGFs. Post...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Methological advances in the examination of the dopamine system in brain
(2005-11-18)
) examination of the interaction between D2/D3 receptors and G proteins in human brain in vitro, (ii) selective visualization of D3 receptors with PET, and (iii) improvement of the accuracy in PET imaging of D2/D3 receptors by correction for partial volume...