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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
(SNP) in the CCL11 gene and related the presence of the former to the plasma CCL11 concentrations, measured by ELISA. There were no differences in CCL1 genotype frequencies between patients and controls. Patient G/G carriers had higher circulating CCL11...
Giardiasis in Leon, Nicaragua : prevalence and protection
(2006-11-20)
conditions. In a subsequent study a prevalence of 15.6 % of anti-Giardia antibodies in milk was detected in lactating women.
The protective effect of milk anti-Giardia antibodies against G. intestinalis infection was studied in 307 children aged 1 week...
High resolution genomic tools for the discovery of protein function in mammalian cells
(2006-05-19)
proteins: (1) a membrane-bound O-acyltransferase protein (C3F) that, when overexpressed, disrupts Golgi and endosome integrity due likely to an ER-Golgi transport block, and (2) a tumor marker (BC2) that prompts a redistribution of a transcriptional...
Neurogenesis, neural stem cells and nitric oxide in neuroinflammation
(2005-09-23)
, the extent of CNS inflammation and demyelination. Intrathecal administration was more effective than systemic administration. The observed effect was accompanied by enhanced anti-MOG IgG1 production.
Next we examined if NOS and reactive oxygen species (ROS...
Aspects on the etiology of esophageal and gastric cancer
(2004-11-12)
completeness of the Cancer Register of 98.3%, while the site-specific accuracy was only 63% for esophageal adenocarcinoma, 74% for gastric cardia adenocarcinoma, and 91% for esophageal squamous-cell carcinoma. The increasing incidence rate of esophageal...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
-carboxaldehyde and 1,4-diacetyl-2,5-piperazinedione ill the presence of caesium carbonate. Several analogues of dipodazine, together with a few barettin analogues have been prepared and tested for activity ill antifouling assays, results and relevance of which...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
), Presenilin 1 (PSEN1), and Presenilin 2 (PSEN2) have been described to cause the early-onset familial form of AD. However, the discovery of genes involved in sporadic late-onset AD has proven to be more difficult. Apolipoprotein-E (APOE) which mediates lipid...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-component reactions between isatin, alpha-amino acid derivatives, and suitable dipolarophiles. Condensation between isatin and an alpha-amino acid yielded a cyclic intermediate, an oxazolidinone, which decarboxylate to give a 1,3-dipolar species, an azomethine ylide...
Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
(2005-03-25)
dysfunction in prion diseases. For this purpose I used an immortalized gonadotropin-releasing neuronal cell line (GT1-1) that is susceptible to a mouse-adapted scrapie strain. This cell line represents a suitable system for my studies since the cells possess...