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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Regulation of tartrate-resistant purple acid phosphatase by proteolytic processing in rat
(2005-02-25)
inhibitory interactions to active site residues affecting the Fe2+. Conversion of Ser1 45 or Asp 146 into Ala, which should eliminate the putative interaction of the side chains with the active site residues Asn91 or His92, resulted in increased enzyme...
Development of AIDS associated and endemic Kaposi sarcoma : HHV-8/KSHV viral load in cutaneous and oral tumor cells
(2006-09-05)
Kaposi's sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion which usually presents as a cutaneous lesion and eventually progresses to systemic disease usually in the gastrointestinal (G1) tract, lungs, ...
Analysis of global gene expression in complex biological systems using microarray technology
(2006-01-06)
marker (VH3-21) was used to distinguish between two BCLL populations. The result showed a distinct expression profile for VH3-21+ B-CLL vs. non- VH3-21+ B-CLL. Our novel finding of a specific 'VH3-21 profile' strengthens the suggestion that this group...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-component reactions between isatin, alpha-amino acid derivatives, and suitable dipolarophiles. Condensation between isatin and an alpha-amino acid yielded a cyclic intermediate, an oxazolidinone, which decarboxylate to give a 1,3-dipolar species, an azomethine ylide...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
coupling with 6-bromotryptophan methyl ester, as in the case of 8,9-dihydrobarettin, or as a phosphonate derivative in a Homer-Wadsworth-Emmons reaction with 6-bromoindole-3carboxaldehyde, as in the key step in the synthesis of barettin. Both barettin and 8...
Genetic studies of follicular and mantle cell lymphoma
(2005-04-22)
cell lymphomas has a post germinal center origin. It was further demonstrated that there was a preferential V H3-21 usage in 19% of the tumors, and that patients with tumor usage of this V H-gene had a longer survival compared with the rest...
The insulin-like growth factor system : effects of circulating proteases
(2005-08-18)
factors. In scrum most IGF circulate in a ternary complex with IGF-binding protein-3 (IGFBP-3) and the acid labile subunit (ALS). The affinity between IGF and IGFBP-3 exceeds that between IGF and the type 1 IGF receptor demonstrating that most...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...
Off-label drug treatment and related problems in children : a register-based investigation
(2006-04-21)
Introduction: There is a lack of pediatric documentation concerning efficacy and safety of many drugs, which may contribute to off-label drug treatment and increase the risk for adverse drug reactions (ADRs).
Aims: ...