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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Biological aspects of synovial fluid mediated aseptic prosthesis loosening
(2005-08-26)
Aseptic prosthesis loosening is the most common reason for late failure of total hip arthroplasties. Resorption of the peri-prosthetic bone, resulting in a loose prosthesis is characteristic for aseptic loosening. The ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9.5...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Distribution of serotonin receptors and transporters in the human brain : implications for psychosis
(2005-04-22)
The serotonin (5-HT) system is thought to be involved in different
psychiatric disorders, including depression and anxiety disorders, and is
a major target for the pharmacological treatment of these conditions. ...
Safety limit estimation for cataract induced by ultraviolet radiation
(2005-08-12)
times lower than that for 18-week-old rats (study I). Rats aged 18 to 60 weeks had a stable MTD of approximately 5 kJ/m2 (study II). The data from rats aged 3 to 60 weeks were used to derive a general expression for threshold dose (MTD) as a function...
Patellar tendinopathy : on evaluation methods and rehabilitation techniques
(2006-10-27)
Background: Patellar tendinopathy is an increasingly common overuse and degenerative injury for recreational and elite athletes. The management of this injury is often difficult and frustrating and the treatment may take ...
Modeling individual behavioral changes : the case of tobacco uptake in a cohort of school children
(2005-08-25)
The aim of this thesis was to elucidate preventable determinants of smoking and smokeless tobacco use in adolescence in the frame of a longitudinal study (BROMS cohort). The study population encompasses 3019 children recruited from 5th grade classes...
Diagnostic tests for adiposity and metabolic risk factors in adolescence : results from the Stockholm weight development study (SWEDES)
(2005-03-25)
Background: Despite growing concern about the development of pediatric
obesity, there is still controversy about its classification.
International classification systems have been proposed and national
systems are in ...
Molecular mechanisms regulating exocytosis : studies of insulin secretion and neurotransmitter release
(2005-02-11)
expressed in neurons. Cdk5 was identified in pancreatic ?-cells where it functions as a positive regulator of insulin secretion. Although ?-cells expressed both of the identified Cdk5 regulatory subunits, only Cdk5, activated by p39, enhanced insulin...