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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
(SNP) in the CCL11 gene and related the presence of the former to the plasma CCL11 concentrations, measured by ELISA. There were no differences in CCL1 genotype frequencies between patients and controls. Patient G/G carriers had higher circulating CCL11...
Computational prediction of antisense oligonucleotides and siRNAs
(2005-09-02)
Two popular gene knockdown methods, antisense oligonucleotides (AOs) and short interfering RNAs (siRNAs) are commonly used to selectively inhibit gene expression (gene knockdown). This is an extremely valuable tool for ...
Basic and translational studies of follicular thyroid neoplasia
(2005-04-08)
Thyroid tumors occur frequently in the general population and although the majority represents benign follicular adenomas (FTA), thyroid cancer constitutes 1% of all malignancies worldwide. Among the differentiated cancers, three main types...
Kostmann syndrome : a clinical and pathophysiological study
(2004-10-15)
Kostmann syndrome or severe congenital neutropenia (SCN) is a rare disease, usually diagnosed during the first months of life, characterized by extremely low levels of neutrophils in the peripheral blood, a maturational ...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
)] and 841 woman [mean age = 35.7 years (±2.9 SD)] who participated in an epidemiological study of periodontal health that was started in 1985, 2.4 % were found to exhibit foetor ex ore and 1 % were diagnosed as having halitophobia. Subjects with both...
Occupational exposure to pesticides and risk of leukemia among offspring in Costa Rica
(2006-11-03)
of 1-4 and 5-9 years of age and for three out of seven geographical regions. Based on the first 100 ICF, recall was acceptable in 90% of the interviews, successful identification of special events in 84%, good recovery of pesticide names, frequency...
Immunogenicity of and apoptosis modulation by Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) : implications for nasopharyngeal carcinoma
(2005-05-19)
which enable the virus to efficiently immortalize B lymphocyte and also transform cells of other types. Among the viral genetic products, a membrane integral latent infection protein, latent membrane protein-1 (LMP1) is of particular interest, since...
Epstein-Barr virus nuclear antigen 1, Oct and Groucho/TLE in control of promoter regulation
(2005-11-04)
The human herpes virus Epstein-Barr virus (EBV) is carried by
approximately 95% of the adult population. It can form a lifelong latent
infection in the B-cells by avoiding our immune system. A latent EBV
infection is ...
Modeling individual behavioral changes : the case of tobacco uptake in a cohort of school children
(2005-08-25)
The aim of this thesis was to elucidate preventable determinants of smoking and smokeless tobacco use in adolescence in the frame of a longitudinal study (BROMS cohort). The study population encompasses 3019 children ...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
to the health and population-based registers. Cancer had been notified to the cancer register for 1,575 of the subjects (only initial notification of cancer detected after day of entry into the study was included); 3,630 had died during the follow-up time...