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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Physical capacity in individuals with cerebral palsy : problems, needs and resources, with special emphasis on locomotion
(2005-09-09)
). The individuals were in four tests instructed to walk as far as possible for six minutes. The distance walked, heart rate and perceived exertion were assessed. The walked metre averaged 316 (range 74-579), 336 (range 65621), 341 (range 83-626) and 345 (range 88...
The fate of primary aneuploid cells in early embryonic development and stem cells
(2005-09-02)
Chromosomal aberrations occurring during gametogenesis and early embryonic development play a significant role in infertility and fetal loss in humans. Germ cells that have an abnormal number of chromosomes (aneuploidy) ...
Clinical, immunological and olfactory aspects of sinusitis and nasal polyposis : with special reference to patients with cystic fibrosis
(2004-11-26)
The otorhinolaryngological approach to the problem concerning
rhinosinusitis and nasal polyposis in the recessive genetic disorder of
cystic fibrosis (CF) has been developed based on data from international
studies. ...
Viridans group streptococci septicaemia and endocarditis : molecular diagnostics, antibiotic susceptibility and cinical aspects
(2005-04-27)
Viridans group streptococci (VGS) are inhabitants in the oral cavity and in the gastrointestinal tract. They cause severe infections, they are responsible for up to 39 % of the cases of septicaemia in neutropenic patients ...
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis in vivo. The following...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities.
In the first part of this thesis we could establish and confirm ...
Environmental factors and p53 mutation spectrum in lung cancer
(2006-05-19)
), residential radon and arsenic on the p53 mutation prevalence and spectrum in lung tumors. Furthermore, we investigated the lung cancer risk among 316 cases and 727 controls in the area surrounding Rönnskärsverken, a non-ferrous metal smelter, and cases from...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Cholinergic receptors in human prenetal brain : presence, distribution and influence of nicotine and ethanol
(2005-03-18)
Events early in life, including exposure to various compounds, may cause
disturbances in brain development. Both maternal smoking and alcohol
drinking during pregnancy can induce preand postnatal death, cognitive
and ...