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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
plaques, where it colocalized with macrophages, endothelial cells, and smooth muscle cells (SMC). Human coronary artery SMC exposed to either the LTB4 Or the BLT1 partial agonist U75302 exhibited increase of whole-cell ion currents indicating...
Characterization of the cellular receptor for coxsackievirus and adenovirus
(2006-08-25)
CAR, the cellular receptor for coxsackievirus and adenovirus, was discovered in 1997. CAR is an evolutionary conserved transmembrane protein that belongs to the CTX subfamily within the large immunoglobulin superfamily. ...
Hormones and breast cancer : aspects on receptor expression and metabolism
(2006-02-17)
Breast cancer is the most common malignancy among women in the western world. Sex steroid hormones are implied as risk factors but endocrine regimens are also used in the therapy of breast cancer. Current knowledge about ...
Leukotriene A4 hydrolase : studies of structure-function relationships by site-directed mutagenesis and X-ray crystallography
(2004-10-15)
system. The inflammatory process
is a complex array of interactions between cells and soluble factors,
among which are the leukotrienes, a family of lipid mediators.
Leukotriene (LT) B4 is a chemical mediator of inflammation. It is a
potent chemotactic...
Genome characterisation and mobility investigation in trypanosomes
(2006-02-16)
Trypanosomes are uni-flagellated protozoa responsible for some of the most debilitating human infections such as Chagas disease (Trypanosoma cruzi) and sleeping sickness (Trypanosoma brucei). Unravelling their genome ...
Develop your memory strategies! Self-generated versus mnemonic strategy training in old age : maintenance, forgetting, transfer and age differences
(2005-04-08)
The general aim of this thesis was to further our understanding of
episodic memory plasticity in normal aging, by examining the
effectiveness of a mnemonic-strategy training program versus a
self-generated memory strategy ...
Wnt signalling in the development of ventral midbrain dopaminergic neurons
(2004-12-24)
Dopaminergic (DA) neurons in the ventral midbrain (VM) are one of the major cell types lost in Parkinson's disease (PD). Proof-of-principle exists for cell replacement therapies for PD, but wider application is halted by ...
Catalytic mechanisms and evolution of leukotriene A4 hydrolyse
(2006-11-10)
of chemical mediators, which by different means control, maintain and resolve the process. One group of such mediators is the leukotrienes, among which LTB4 is found. LTB4 has several immunomodulating properties and mainly acts by recruiting leukocytes...
Unstimulated human whole saliva flow rate in relation to hyposalivation and dental caries
(2005-04-08)
Introduction: Salivary secretion is influenced by a large number of factors, including the circadian rhythm, making the detection of reduced salivary flow (hyposalivation) difficult. This is important since severely reduced ...
Incidence and prognosis of differentiated thyroid cancer in Sweden
(2006-01-06)
Non-medullary differentiated thyroid cancer (DTC) is a rare disorder but, nevertheless, among the most common cancers in individuals below 40 years of age. DTC consists of papillary (PTC) and follicular (FTC) thyroid cancer. ...