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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
(SNP) in the CCL11 gene and related the presence of the former to the plasma CCL11 concentrations, measured by ELISA. There were no differences in CCL1 genotype frequencies between patients and controls. Patient G/G carriers had higher circulating CCL11...
Regulation of tartrate-resistant purple acid phosphatase by proteolytic processing in rat
(2005-02-25)
inhibitory interactions to active site residues affecting the Fe2+. Conversion of Ser1 45 or Asp 146 into Ala, which should eliminate the putative interaction of the side chains with the active site residues Asn91 or His92, resulted in increased enzyme...
Foregut motility disorders : a clinical and experimental study
(2004-08-13)
Objective: To investigate some clinical aspects and treatment modalities
of foregut motility disorders and to experimentally explore some
mechanisms involved. Special emphasis has been put on elucidating and
evaluating ...
Urinary leakage and physical activity in young women
(2005-11-18)
, II, IV and V included 1230 women (725 primiparous, 305 ex-trampolinists and 200 women with LBP), mean age 28 (range 17-45) years, who answered the same questionnaire with questions regarding physical activity, micturition habits and UL...
Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts
(2005-11-11)
inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. Enhanced expression of MMPs including MMP-1 and MMP-3 is demonstrated in gingival connective tissue of individuals with periodontal...
Chromatin structure and histone modifications in gene regulation
(2006-11-24)
linker histone H1 binds at the DNA entry/exit site of the nucleosome and organises the linker DNA and influence higher order chromatin structure. In order to induce gene expression the transcription factors, coactivators and also the transcriptional...
Mental and physical health among first-generation and second-generation immigrants in Sweden
(2006-09-11)
hospitalized for mental disorders than the Swedish majority population after adjustment for socioeconomic status (study 1 ). To study whether the increased risk of being hospitalized for psychotic disorders among certain immigrant groups is present among second...
Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
(2005-03-25)
dysfunction in prion diseases. For this purpose I used an immortalized gonadotropin-releasing neuronal cell line (GT1-1) that is susceptible to a mouse-adapted scrapie strain. This cell line represents a suitable system for my studies since the cells possess...
Risk factors for haematological malignancies : immune-mediated diseases, body mass index and magnetic fields
(2006-11-03)
Haematological malignancies constitute approximately 7% of all cancer cases in Sweden, and leukaemia is in fact the most common malignancy among children. The few established risk factors, such as ionising radiation and ...
Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs
(2005-05-13)
), thereby amplifying cAMP/PKA-mediated responses. Haloperidol also stimulates the phosphorylation of the two mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinases 1 and 2 (Erk1/2). In addition, haloperidol phosphorylates...