Search
Now showing items 1-10 of 262
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol lowering drugs in Alzheimer's disease
(2006-05-12)
in AD treatment.
Paper I investigated the levels of individual nAChR subunits on primary rat astrocytes and the possible direct influence of Abetas on nAChRs in the cells. The alpha4, alpha7, beta2 and beta3 nAChR subunits and related calcium channel...
An epidemiological study og drug-induced acute pancreatitis utilizing a Swedish case-control network
(2006-01-06)
.2-4.8), for proton pump inhibitors 2.1 (1.2-3.4), for non-steroidal anti-inflammatory drugs derived from acetic acid 2.3 (1.3-4.0) and for antibacterial agents designed for systemic use 1.9 (1.1-3.2). Inflammatory bowel disease exhibited an OR of 3.4 (1.5-7.9), while...
Brain cholesterol metabolism : a study of mouse and man
(2005-09-16)
. Preliminary findings also indicated that
7alphahydroxy3-oxo-4-cholestenoic acid may be fluxing out of the brain, a
steroid which can be formed in the brain from 27hydroxycholesterol.
Cholesterol 24-hydroxylase or CYP46A1, oxidises cholesterol to
24S...
Idiopathic thrombocytopenic purpura in childhood : clinical features, diagnostics and treatment
(2004-10-29)
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder
characterized by thrombocytopenia, i.e. platelet count (pl.c.)
<150x109/L, due to antibody binding to platelet antigen(s) causing their
rapid destruction ...
Directed differentiation of adult neural stem cells for cell therapy in the nervous system
(2005-04-29)
The emergence of neural stem cell research has raised hopes for cell therapy of neurological disorders. Insight into the normal mechanisms of neural stem cell fate specification and differentiation is a prerequisite for ...
Biological importance of cytomegalovirus infection in health and disease : profound effects of infection on monocyte and smooth muscle cell function
(2005-01-28)
Human cytomegalovirus (HCMV) is a herpesvirus. Following a primary
infection, HCMV persists in the body in a latent form and most adults are
virus carriers. Infection and reactivation of HCMV occur in
inummocompromised ...
Leukemia chemotherapy : experimental studies on pharmacological optimisation
(2004-11-26)
Our main goal has been to identify new means to improve chemotherapy of
acute leukaemia:
1. By using low-density lipoprotein (LDL) as a drug carrier to increase
the selectivity of antileukemic drugs, based on high LDL ...
The role of the endothelin system in experimental acute lung injury : with special reference to the formation of extra-vascular lung water
(2006-05-12)
Acute lung injury is a major clinical challenge in the intensive care unit. Sepsis is the most frequent underlying cause of this pulmonary syndrome, which contains inflammation-induced diffuse alveolar damage and early ...
Molecular characterization of the Ro52 autoantigen and its disease related epitopes
(2005-01-14)
The presence of high titers of autoantibodies in patient sera is characteristic for the autoimmune disorder Sjögren s syndrome. The major targets for these autoantibodies are three intracellular proteins Ro52, Ro60 and La. ...