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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
-PSOX, which mediates uptake of oxidized low-density lipoprotein (oxLDL) by cells. We detected abundant CXCL16/SR-PSOX and CXCR6 expression in atherosclerotic lesions from human subjects and apolipoprotein-Edeficient (ApoE-/-) mice. In monocytes, CXCL16/SR...
Teenage parenthood : paternal characteristics and child health outcomes
(2004-08-13)
1987-93 who were followed prospectively in registers from birth to their seventh birthday regarding hospital admissions for unintentional and violent injuries. The study population in Paper IV included the 292.129 children born to primiparas in 1973...
Psychosocial risk factors in women with coronary heart disease : stress, social support and a behavioral intervention
(2005-09-16)
to survey psychosocial and physiological risk factors for CHD in women. Participants were 292 women <65 years (mean age 55±8 yrs) recruited while hospitalized, for acute myocardial infarction (AMI) or unstable angina pectoris from all hospitals in Stockholm...
Sleep and cardiovascular health in women : the Stockholm female coronary risk study
(2004-11-12)
comprises 292 women aged 65
years or younger who were admitted for an acute event of CHD between 1991
and 1994 in any of the coronary care units of all hospitals in the
greater Stockholm area. Age matched healthy controls from the census
register were...
The megencephaly mouse : from gene to neuronal proliferation
(2005-12-23)
chromosome 6.
The aims of this thesis was to identify the mceph mutation, perform functional studies of the MCEPH protein and to characterize the brain enlargement.
Using a positional cloning approach the mceph mutation was identified as an 11 bp...
Functional domains in the Alzheimer's disease-associated presenilin 1 protein
(2004-10-29)
Alzheimer's disease (AD), the most common cause of dementia, is
neuropathologically characterized by the presence of neurofibrillary
tangles and amyloid plaques in the brain. Amyloid plaques are
extracellular deposits ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods
(2006-03-17)
Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available ...
Coronary artery bypass surgery without extracorporeal circulation
(2006-03-10)
Introduction: Coronary artery bypass surgery with extracorporeal circulation is associated with a systemic inflammatory response syndrome that contributes to morbidity and mortality. Aortic cross clamping and cardioplegic ...