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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Rotavirus in pediatric gastroenteritis in Nicaraguan children
(2004-10-26)
cost of more than USD 270,000 from the Health
care sources. If all cases of severe diarrhea are considered, including
other etiologies of gastroenteritis, the total cost burden amounts to
more than USD 800,000, a sum that represents around 0...
Structural diversity of the lipid A and core oligosaccharide moieties of the lipopolysaccharides from nontypeable and serotype f Haemophilus influenzae
(2005-11-04)
This thesis describes structural studies of the oligosaccharide and lipid A moieties of lipopolysaccharides (LPSs) isolated from disease-causing Haemophilus influenzae strains. The nontypeable strains were clinical isolates ...
On aspects of context in rehabilitation after stroke : views of patients and therapeutists
(2006-09-15)
Contextual factors have lately come more into focus contributing to the individual's health condition. Previous research indicates that contextual factors are poorly accounted for in stroke rehabilitation and that the ...
Leukotriene A4 hydrolase : studies of structure-function relationships by site-directed mutagenesis and X-ray crystallography
(2004-10-15)
agent for polymorphonuclear leukocytes and
T-lymphocytes, and thus constitutes an important link between the innate
and adaptive immune responses. LTB4 is formed from arachidonic acid by
the sequential action of 5-lipoxygenase and LTA4 hydrolase (LTA4H...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9.5...
Distribution of serotonin receptors and transporters in the human brain : implications for psychosis
(2005-04-22)
The serotonin (5-HT) system is thought to be involved in different
psychiatric disorders, including depression and anxiety disorders, and is
a major target for the pharmacological treatment of these conditions. ...
Ethyl glucuronide : a new biochemical marker for acute alcohol intake : studies on possible causes for false-negative or false-positive results
(2006-02-17)
, such as ethanol, 5-hydroxytryptophol(5HTOL), ethyl glucuronide (EtG) and ethyl sulfate (EtS), and 2) tests that are able to detect chronic heavy drinking, or indicate body organ or tissue damage caused by long-term exposure to alcohol, such as carbohydrate...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...