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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
The influence of psychosocial stress, socioeconomic differences and coffee consumption in the etiology of type 2 diabetes
(2004-12-24)
Type 2 diabetes is a chronic disease of multiple etiology and with increased prevalence during the past two decades. We investigated the influence of psychosocial stress in association with type 2 diabetes and looked further into possible...
Regression on high-dimensional predictor space : with application in chemometrics and microarray data
(2004-11-26)
This thesis focuses on regression methodology for prediction and
classification in situations where there are many predictors but limited
number of observations. This situation is common in chemometrics and
microarray ...
Influence of exposure patterns and oxidation in UVR-induced cataract
(2005-04-29)
. To investigate the additive effects of radiation exposure in UVR-induced cataract. 2. To evaluate the validity of the reciprocity law for UVR-induced cataract. 3. To deter mine whether vitamin E may protect against UVR-induced cataract. 4. To investigate...
On lumbar spinal stenosis and disc herniation surgery
(2005-04-01)
. The mortality rate declined despite ageing spinal stenosis patients. The length of stay after surgery was reduced to half. Patients operated on for spinal stenosis and disc herniation have a risk of being reoperated after one and ten years of 2-3 %, and 10...
Women’s encounters with biomedical technology in the realm of cervical cancer screening
(2004-12-31)
As a form of biomedical technology, the Papanicolaou (Pap) smear has been described as the most widely used and established cane er- screening tool in the world. In Sweden, Pap smear technology triggered what is today an ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Temporal monitoring of intracellular Ca2+ signaling and origins of Ca2+ oscillations
(2006-04-07)
This thesis examined parameters influencing stimulated cytoplasmic free Ca2+ concentration ([Ca2+]i) oscillations in hepatocytes and pancreatic beta-cells. Hepatic glucose output is regulated in part by hormones such as vasopressin that act through...
Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs
(2005-05-13)
The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. haloperidol, reduce...
Family history and breast cancer susceptibility : clinical and molecular studies
(2006-09-15)
with a more modest increased risk of the disease. Mutations in the known high risk genes BRCA1, BRCA2 and p53 account for less than 25% of the familial risk for breast cancer, while the remainder remain genetically unexplained despite a large effort...