Search
Now showing items 1-10 of 294
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Functional domains in the Alzheimer's disease-associated presenilin 1 protein
(2004-10-29)
(Asp-257 and
Asp-385) are thought to form the catalytic site of the enzyme complex.
The PS protein is endoproteolytically cleaved to generate an N-terminal
fragment (NTF) and a C-terminal fragment (CTF) that forms an NTF/CTF
heterodimer in the active...
Characterisation of psoriasis lesions by protein expression profiling
(2006-05-26)
Psoriasis is a common inflammatory skin disease affecting approximately 2% of the population in Sweden. Psoriasis displays clinical heterogeneity leading to several different types of manifestations, among them chronic ...
Esophageal stenting in the palliation of malignant strictures
(2005-12-30)
Background: The prognosis among patients with esophageal or cardia cancer is worse than that in most cancer diseases. Moreover, more than half of the patients with carcinoma of the esophageal or gastric cardia diagnosed ...
On lumbar spinal stenosis and disc herniation surgery
(2005-04-01)
Patients with spinal stenosis and disc herniation are most common in spine surgery. Few population based studies of these patients have been made and no studies of their health related quality of life (HRQOL) by the EQ-5D ...
AMP-activated protein kinase : the connection between exercise and type II diabetes
(2004-11-18)
Skeletal muscle insulin resistance is a hallmark feature of Type 2
diabetes. Physical exercise/muscle contraction elicits an
insulin-independent increase in glucose transport and perturbation of
this pathway can bypass ...
Bad breath : prevalence, periodontal disease, microflora and inflammatory markers
(2005-03-29)
Bad breath usually originates within the oral cavity and is believed to be associated with periodontal disease. The over all aim of the present thesis was to study periodontal conditions in subjects with bad breath as well ...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection
(2006-02-24)
The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. A primary focus of this thesis...
Pituitary autoantibodies in endocrine disorders
(2005-09-30)
by immunoblotting. Reactivity to a M, 49 000 pituitary autoantigen was significantly more frequent in patients with idiopathic pituitary hormone deficiency (6/21 (28%) p< 0.05) as well as their relatives (10/35 (28%) p<0.02) compared to control subjects (3/44 (6.8...