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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Tuberculosis control in Vietnam : directly observed treatment, short-course (DOTS) : the role of information and education
(2004-11-15)
covering 1,384 person-years of
observation over a two and a half-year period. Knowledge and practices
regarding TB care were assessed among 253 health care staff in Bavi
district. Knowledge about TB and its treatment was examined among 364 TB
patients in 42...
Immunotherapy with the anti-EpCAM monoclonal antibody and cytokines in patients with colorectal cancer : a clinical and experimental study
(2005-11-18)
NK cells should be considered to MAbbased treatment regimens.
The addition of GM-CSF, alpha-interferon and 5-fluorouracil to anti-EpCAM mMAb seemed to improved the antitumor response rate compared to historical control patients treated with anti...
Modulation of immune responses in experimental autoimmune encephalomyelitis
(2005-04-13)
The aim of this thesis work has been to elucidate mechanisms for modulation of the immune response in experimental autoimmune encephalomyelitis (EAE), the animal model for the human disease multiple sclerosis (MS).
MS ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9.5...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Distribution of serotonin receptors and transporters in the human brain : implications for psychosis
(2005-04-22)
The serotonin (5-HT) system is thought to be involved in different
psychiatric disorders, including depression and anxiety disorders, and is
a major target for the pharmacological treatment of these conditions. ...
Unstimulated human whole saliva flow rate in relation to hyposalivation and dental caries
(2005-04-08)
Introduction: Salivary secretion is influenced by a large number of factors, including the circadian rhythm, making the detection of reduced salivary flow (hyposalivation) difficult. This is important since severely reduced ...
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(2005-05-17)
The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...
Local and systemic inflammatory mediators and their relation to pressure-pain threshold and pain of the temporomandibular joint
(2006-11-17)
condyle with a hand-held electronic pressure algometer (Somedic Production AB, Sollentuna, Sweden). TMJ pressure-pain threshold is systemically modulated and not modulated by the investigated inflammatory mediators (5-HT, TNFα, IL-1sRII) in the TMJ...