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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
-PSOX, which mediates uptake of oxidized low-density lipoprotein (oxLDL) by cells. We detected abundant CXCL16/SR-PSOX and CXCR6 expression in atherosclerotic lesions from human subjects and apolipoprotein-Edeficient (ApoE-/-) mice. In monocytes, CXCL16/SR...
Familial hypercholesterolemia in Sweden : genetic and metabolic studies
(2004-08-27)
Familial hypercholesterolemia (FH) is inherited as an autosomal
codominant disease, usually caused by mutations in the LDL receptor
(LDLR) gene. Heterozygous FH is a common disease with a prevalence of
about 1/500 in ...
Laparoscopic and open surgery for colon cancer : studies on costs and health related quality of life
(2006-05-19)
(LCR vs. OCR difference of means E 1846, p=0. 104). However, LCR was more expensive than OCR at operation (E 1 171, p<0.001), for the first admission (E 1556, p=0.015) and for the health care system (E 2 244, p=0.018).
In Paper II the method...
On gallstone disease : complications and surgical treatment
(2005-11-18)
, with or without CBDS in 24.4%. In the long-term study of LCBDE, 90% of the questionnaires were returned at a mean follow-up of 36 months. Six re-interventions had been performed, but no suspicion of bile duct stricture or mortality related to the prior surgery...
Immunotherapy with the anti-EpCAM monoclonal antibody and cytokines in patients with colorectal cancer : a clinical and experimental study
(2005-11-18)
The tumor-associated antigen EpCAM (epithelial cell-adhesion molecule) (C017-1A) is over expressed by various human carcinomas, including colorectal carcinoma (CRC). This antigen can be used as a target structure for ...
Genetic susceptibility to breast and endometrial cancer
(2004-09-10)
Hormones are central in the carcinogenic process in the breast and in the uterine epithelium. Individual genetically determined variation in the response to hormonal influence may alter susceptibility to breast and endometrial ...
Modulation of immune responses in experimental autoimmune encephalomyelitis
(2005-04-13)
The aim of this thesis work has been to elucidate mechanisms for modulation of the immune response in experimental autoimmune encephalomyelitis (EAE), the animal model for the human disease multiple sclerosis (MS).
MS ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available ...
Patient-orientated aspects of the postoperative course after hernia surgery
(2006-09-01)
on the discordance between the patient's and the surgeon's perception of complications. Some 206 patients having surgery for inguinal hernia were invited to a follow-up 3-6 weeks after the operation. The patient was asked to fill in a questionnaire with 12 questions...
Human salmonellosis : impact of travel and trade from a Swedish perspective
(2006-09-08)
of import rules, but also how this trend could be broken by active information. In Paper II, we showed the risk of travel-associated salmonellosis to be highest in East Africa and the Indian subcontinent. Children aged 0-6 years were at higher risk than...