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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Resistance to antiviral drugs in HIV and HBV
(2005-02-18)
Development of resistance to antiviral drugs is a major problem in treatment of several viral infections including human immunodeficiency type 1 (HIV-1) and hepatitis B virus (HBV). Resistance may be the primary reason for ...
Esophageal stenting in the palliation of malignant strictures
(2005-12-30)
Background: The prognosis among patients with esophageal or cardia cancer is worse than that in most cancer diseases. Moreover, more than half of the patients with carcinoma of the esophageal or gastric cardia diagnosed ...
Genome characterisation and mobility investigation in trypanosomes
(2006-02-16)
lle strain) and T cruzi I strains, Sylvio X10/7 and CAI/72. A total of 239 eDNA markers have been hybridised to PFGE separated chromosomes and their pattern of hybridisation revealed a highly complex genome organisation.
Many homologous chromosomes...
Metalloproteinases in development and disease
(2004-08-06)
Metalloproteinases are Zn-dependent proteases composed of five superfamilies. One important subfamily is the matrix metalloproteinases (MMPs) that process various components of the extracellular matrix (ECM) and non-ECM ...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...
Safety limit estimation for cataract induced by ultraviolet radiation
(2005-08-12)
Background: Ultraviolet radiation (UVR) is considered one of the major risk factors for agerelated cataract. UVR-induced cataract follows a continuous dose-response function. The concepts maximum acceptable dose (MAD) and ...
Physical activity in rheumatoid arthritis
(2006-04-28)
Physical activity confers health benefits in the general population and should also be applied to people with rheumatoid arthritis (RA). However, there is a need for more research in this area. The aim of this thesis was ...
Hidden Markov models for remote protein homology detection
(2005-12-23)
Genome sequencing projects are advancing at a staggering pace and are daily producing large amounts of sequence data. However, the experimental characterization of the encoded genes and proteins is lagging far behind. ...
Diabetes, physical activity and endometrial cancer
(2006-11-22)
Accumulating evidence suggests that hyperinsulinemia, in the context of insulin resistance, is associated with carcinogenesis. Physical activity is involved in the regulation of metabolic and hormonal pathways and is an ...