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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Protein folding, stability and recognition
(2004-10-29)
Proteins make up for most of the dry mass of a cell and they are highly involved in virtually all cellular processes. The importance of the proteins is reflected by frequent association between dysfunctional proteins and ...
The natural history of HIV-1 infection and preparations for HIV vaccine trials in Tanzania
(2006-09-08)
useful information for HIV intervention strategies, including vaccine development.
Prevalence of sexually transmitted infections (STI's) at baseline among the workers was 16.6% (236/1422) and 15.5% (72/465) in males and females respectively, p=0...
Intake of fruit and vegetables in European children and their mothers, folate intake in Swedish children and health indicators : overweight, plasma homocysteine levels and school performance
(2005-11-18)
An adequate fruit and vegetable intake provides essential nutrients and
nutritive compounds and is considered an important part of a healthy
lifestyle. Within the Pro Children project, an instrument for assessment
of ...
The effects of some peptide hormones on osteoblast-like cells : with specific focus on oxytocin and vasopressin
(2005-01-07)
The nonapeptides oxytocin (OXT) and vasopressin (AVP) are mainly produced in the hypothalamus and released into the circulation through the neurohypophysis. Recently, an OXT-receptor was demonstrated in human osteoblast-like ...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Targeting insulin-like growth factor-1 receptor in cancer
(2004-09-24)
Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. ...
Distribution of serotonin receptors and transporters in the human brain : implications for psychosis
(2005-04-22)
The serotonin (5-HT) system is thought to be involved in different
psychiatric disorders, including depression and anxiety disorders, and is
a major target for the pharmacological treatment of these conditions. ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
PET studies of the serotonin transporter in the human brain
(2006-10-27)
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination...