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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Familial hypercholesterolemia in Sweden : genetic and metabolic studies
(2004-08-27)
Familial hypercholesterolemia (FH) is inherited as an autosomal
codominant disease, usually caused by mutations in the LDL receptor
(LDLR) gene. Heterozygous FH is a common disease with a prevalence of
about 1/500 in ...
Socio-demographic determinants of pregnancy outcomes and infant growth in transitional Russia
(2005-02-16)
There is a growing body of literature exploring social, demographic, and life-style factors in relation to pregnancy outcomes and infant growth patterns. However, only a few studies on the topic were conducted in transitional ...
Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia
(2006-01-20)
-DC and compared it to the T-cell stimulatory capacity of DC that were fused with tumor cells. Following overnight incubation 22.6 ± 6.2% (mean ± SEM) of DC had endocytosed apoptotic leukemic cells while the frequency of DC-leukemic cell hybrids was 10.5 ± 2.6%. A...
Arthritogenic and immunogenic properties of modified autoantigens
(2005-03-22)
Rheumatoid arthritis is a chronic inflammatory joint disorder with autoimmune features in which both genetic and environmental factors are potential contributors to the arthritogenic process. In this thesis work we aimed ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
AIDS and endemic Kaposi's sarcoma development : comparison by histopathology, virology (HHV8/KSHV) and cytogenetics
(2005-08-30)
Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like
lesion with spindle cells (SC) affecting the skin, lymphnodes and viscera
which is found in four different clinico-epidemiological forms as Classic
KS ...
Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection
(2006-02-24)
The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. A primary focus of this thesis...
Induction of t-cell responses against PSA by plasmid DNA immunization
(2005-05-20)
expressed by prostate epithelial cells after malignant transformation and thus can be considered a tumor-associated antigen for prostate cancer. In our studies we investigated the potency of DNA vaccines to induce PSA-specific CD8+ cytotoxic T lymphocytes...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...