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Synthesis of sulfur and selenium heterocycles, including derivatives of imidazopyridine and benzimidazole
(2005-11-24)
. The second part concentrates on the palladium-(0)catalyzed cross-coupling reactions of 4- and 5-substituted 2,1,3-benzoselenadiazoles.
The heterocyclic amines described can be divided into the linear and the angular compounds. Five linear imidazo[4,5-b...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
-PSOX, which mediates uptake of oxidized low-density lipoprotein (oxLDL) by cells. We detected abundant CXCL16/SR-PSOX and CXCR6 expression in atherosclerotic lesions from human subjects and apolipoprotein-Edeficient (ApoE-/-) mice. In monocytes, CXCL16/SR...
Design and synthesis of steroid mimetic libraries using solid phase techniques
(2004-09-10)
This thesis deals with the design and synthesis of biologically active ligands for nuclear hormone receptors using combinatorial techniques.
In the first part, a 5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolin-3(4H)-one tricyclic core structure...
Characterisation of psoriasis lesions by protein expression profiling
(2006-05-26)
to psoriasis is PSORS1 on chromosome 6p21.3, which contains the human leukocyte antigen genes. This association is explained by the overrepresentation of psoriasis patients carrying HLA-Cw*0602. Other loci are known to contribute to psoriasis...
Motor function and cognition : aspects on gait and balance
(2005-11-25)
Introduction: Cognitive dysfunction and dementia are linked to physical
disability and are the major cause of dependency and institutionalization
in the elderly. Physical therapists deal with disability yet little
clinical ...
On testosterone during alcohol withdrawal in men : effects on mood and insulin-like growth factor 1
(2004-11-17)
The decrease of testosterone levels after alcohol ingestion is seen in
both non-alcoholic and alcohol dependent patients. Mood effects during
hangover and alcohol detoxification are common symptoms. In ageing men ...
Esophageal stenting in the palliation of malignant strictures
(2005-12-30)
Background: The prognosis among patients with esophageal or cardia cancer is worse than that in most cancer diseases. Moreover, more than half of the patients with carcinoma of the esophageal or gastric cardia diagnosed ...
Identification of tumor suppressor genes using the approach of gene inactivation test
(2006-05-26)
in one tested cancer cell line. However, all mutated genes and wild type PL6, RhoA, 3PK, BLU, 101F6, MLH1 and others didn't show this activity in the tested cell line(s), although they resided in frequently affected 3p21.3 regions. Some of the newly...
Maternal morbidity in Uganda : studies on life-threatening pregnancy complications in low-income settings
(2004-11-25)
women without post-abortion infection; but this was double the
seroprevalence among antenatal clients in the same hospital, 14.6% in
1997. HIV-1 seroprevalence was significantly higher among women with
postpartum endometritismyometritis (PPEM) than...
Opioid ligands and receptors of the joint
(2006-04-28)
The aim was to explore the occurrence of an opioid system in joints. Thus, joint tissues from rats with and without arthritis and also from patients with knee osteoarthrosis were investigated by EM, immunohistochemistry, ...