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Disassembly and reassembly of the nuclear pore complex
(2006-09-22)
NPC assembly is regulated by a dynamic equilibrium between kinase (Cdk1) and phospahatase (sensitive to OA) activity and that it is spatially coordinated by the Ran GTPase system.
Finally. using the nucleoporin gp210 as a model. we have tested a...
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
(SNP) in the CCL11 gene and related the presence of the former to the plasma CCL11 concentrations, measured by ELISA. There were no differences in CCL1 genotype frequencies between patients and controls. Patient G/G carriers had higher circulating CCL11...
Synthesis of indoles, bisindoles and indolocarbazoles : high affinity aryl hydrocarbon receptor ligands
(2004-09-03)
prepared in a Lewis acid mediated acylation involving different
indoles and indolyl-2-carbonyl chlorides. Synthesis of the metabolites
proved the assigned structures as 2-hydroxy-, 8-hydroxy-,
2,10-dihydroxy-, 4,8-dihydroxy- and 2,8dihydroxyindolo[3,2-b...
The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion
(2004-10-01)
(NO) bioavailability and increased production of endothelin-1 (ET-1). Certain ET-1 receptor antagonists and calcium channels blockers may in addition to their classical actions, affect NO bioavailability.
The aim of the studies was to investigate...
Early oncogenic events and defective apoptosis in prostate cancer
(2005-03-18)
. Moderate to strong staining was observed in 68% of cancers and 97% of HGPIN, negative or weak in benign glands. Pim-1 was overexpressed in HGPIN compared to cancer in 65% of the cases. The data suggest that pim-1 overexpression in HGPIN may be an early...
Upper limb reduction deficiencies in Swedish children : classification, prevalence and function with myoelectric prostheses
(2004-11-26)
. Occupational therapists completed 210 assessments
of 75 persons. Rasch rating scale analysis was used for validation and
reliability estimations. The results demonstrate internal scale and
person response validity.
The external reliability of ACMC...
AMP-activated protein kinase : the connection between exercise and type II diabetes
(2004-11-18)
resistance tissue. An isoform -specific defect in AMPK(alpha)1
activity in response to contraction was observed, which was
inconsequential to glucose transport. Thus, the AMPK signaling to glucose
transport is unaffected by insulin resistance.
The AMPK...
Diabetes, physical activity and endometrial cancer
(2006-11-22)
cancer, we identified 16 studies (3 cohort and 13 case-control studies), and found that diabetes was statistically significantly associated with an increased risk of endometrial cancer incidence, (summary RR = 2.10 95% CI= 1.75-2.53). Analysis of 2...
Occupational exposure to pesticides and risk of leukemia among offspring in Costa Rica
(2006-11-03)
of 1-4 and 5-9 years of age and for three out of seven geographical regions. Based on the first 100 ICF, recall was acceptable in 90% of the interviews, successful identification of special events in 84%, good recovery of pesticide names, frequency...
Kinetics of HIV-1 drug resistance mutations in vivo
(2006-03-10)
Antiretroviral therapy (ARV) exert a selective pressure on HIV-1 and may select viral drug resistant strains which have competitive advantage in the presence of the drug. Knowledge about the appearance and disappearance of these mutations...