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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Drug utilization 90% : using aggregate drug statistics for the quality assessment of prescribing
(2004-08-27)
Introduction: There is room for improvement in prescribing. Although a
range of indicators have been developed to assess the quality of
prescribing, none of them focus on all drugs and there is a gap between
what is ...
Oral mucosal lesions, tobacco use and the long-term outcome in a Swedish population
(2006-11-10)
The overall objectives of this thesis were to study the natural history for Oral Lichen (OLL), Oral Leukoplakia (OL) and Snus Induced Lesions (SIL) and to correlate cancer and mortality among users and non-users of Swedish ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
viral response was achieved more often in patients with ribavirin concentration above the median concentration of 8.7µM, than below the median. Data are suggesting that higher ribavirin concentrations may lead to better treatment response in genotype 1...
Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection
(2006-02-24)
The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. A primary focus of this thesis...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
, both 5HT2AR, being CD3, CD4 or CD8 positive cells, and serotonin transporter protein (SERT) positive cells, being CD1a, CD4, CD8 positive or CD56+ CD3- cells, were increased. 5-HT3R immunoreactivity was seen in the basal epidermis of the inflamed...
Oral health in old age : perception among elderly persons and medical professionals
(2006-09-29)
The general aim of this thesis was to investigate perceptions of oral health among elderly persons and among medical professionals working at primary health care centres. The study samples consisted of elderly persons and ...
Anxiety, exhaustion and depression in relation to periodontal diseases
(2006-03-10)
level in GCF was increased, whereas the patients in Study IV surprisingly showed lower cortisol values in GCF than the controls. The level of cortisol in saliva was similar in both groups. Neither did the levels of matrix metalloproteinases-8, -9 (MMP-8...