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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
(SNP) in the CCL11 gene and related the presence of the former to the plasma CCL11 concentrations, measured by ELISA. There were no differences in CCL1 genotype frequencies between patients and controls. Patient G/G carriers had higher circulating CCL11...
Cyanoacetylation of indoles, pyrroles and amines, and synthetic uses of these products
(2005-02-25)
This thesis is based on an organic synthetic project aimed towards development of small molecules acting on the P2 receptor as well as development of synthetic methods to such molecules (primarily indoles and featuring ...
Synthesis of sulfur and selenium heterocycles, including derivatives of imidazopyridine and benzimidazole
(2005-11-24)
. The second part concentrates on the palladium-(0)catalyzed cross-coupling reactions of 4- and 5-substituted 2,1,3-benzoselenadiazoles.
The heterocyclic amines described can be divided into the linear and the angular compounds. Five linear imidazo[4,5-b...
Studies on vascular remodeling in acute coronary artery disease
(2005-08-26)
preparation. Specific objectives were to compare protease expression, apoptosis and angiogenesis between stable and unstable plaques, to study MMP9 induction in vein grafts after surgical handling, and to explore the impact of cytokines on MMP1 and MMP9...
Disassembly and reassembly of the nuclear pore complex
(2006-09-22)
minor role as a storage compartment for nucleoporins.
We developed a novel in vivo model system based on syncytial Drosophila embryos to study mitotic disassembly/reassembly of the NPC. We found that the major mitotic kinase Cdk1 is the key regulator...
Design and synthesis of steroid mimetic libraries using solid phase techniques
(2004-09-10)
was designed mimicking the ABC-rings of a steroid. The core structure was synthesized from 7,8-dihydroquinoline-2,5(1H,6H)-dione with the AB-rings already in place. Two different approaches towards the preparation of the C-ring were tested, i.e. using either a...
Ancestral influences on health of grandchildren
(2005-03-22)
surfeit of food during his SW, the proband had a fourfold excess mortality related to diabetes (OR 4.1, 95% c.i. 1.33-12.9 p=0.01) when age at death and the effects of parents and other grandparents exposure to food availability during their SGP were taken...
Syntheses of some tri- and tetracyclic heterocycles containing an indole moiety
(2004-11-19)
of the lead compound B-220 is presented. We have described a method for reduction of the biologically interesting indolo[2,3b)quinoxalines with zinc, which are subsequently trapped with an appropriate anhydride to provide the corresponding mono or diacylated 5,1...
Professional identity and competence in practice : self-evaluation of nurses in paediatric care
(2006-09-29)
for their employment, the highest scores were found in consideration (mean 4.05), ambition (mean 3.91) and sensitivity (mean 3.84). The lowest scores were found in grasp of ideas (mean 2.69), leadership (mean 2.73) and discrimination (mean 2.89). Regarding Barriers...
Characterization of toxicological effects of a novel in vivo benzo[a]pyrene metabolite in colonic cells
(2004-09-01)
Cancer of the colon and rectum is the third most common cancer form in the world. Where the majority of cases fall into the category of sporadic colorectal cancer (CRC), lifestyle and diet have been found to be important ...