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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
(SNP) in the CCL11 gene and related the presence of the former to the plasma CCL11 concentrations, measured by ELISA. There were no differences in CCL1 genotype frequencies between patients and controls. Patient G/G carriers had higher circulating CCL11...
Perlecan in vascular disease
(2005-01-28)
Atherosclerosis has become the most common cause of death in the world. The development of the disease involves accumulation of lipids in the inner layer of the vessel wall, the intima, and recruitment of inflammatory cells ...
Effect of estrogen on longitudinal bone growth
(2006-04-14)
Longitudinal bone growth occurs at the growth plate, a thin layer of cartilage between the epiphysis and the metaphysis of long bones. In the growth plate resting chondrocytes proliferate, differentiate into a hypertrophic ...
Methods and detection of endogenous peptides in the CNS and GI tract
(2006-11-15)
Endogenous peptides, such as enkephalins, endorphins and orexins modulate a variety of biological processes; these peptides are found in the central nervous system and periphery, including the gastrointestinal tract. One ...
Serodiagnosis and seroprevalence of Helicobacter pylori infection in Vietnam
(2006-10-19)
from 971 individuals (age 1-88 years) in urban Hanoi and rural Ha Tay. Of these samples, 432 adults (18-88 years) from Hanoi were included in the serological evaluations and all 1971 individuals in the seroep idem io logical study.
Methods...
Liver transplantation and the role of adjuvant therapy for advanced primary liver tumours
(2005-11-11)
Liver transplantation (LT) for unresectable locally advanced primary liver tumours (aPLT) is associated with an inferior survival compared to other established indications. As organ shortage in most regions is the major ...
Pet imaging of two monoaminergic neurotransmitter systems in brain : studies of the norepinephrine transporter and dopamine D[2] receptor
(2006-11-23)
and 5-HT1A receptor occupancy in brain after administration of RGH-188. In addition, the intrinsic activity of RGH-188 was estimated in vivo using a dopamine D2 agonist and antagonist radioligand. RGH-188 occupied D2 receptors in a dose dependent...
Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts
(2005-11-11)
inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. Enhanced expression of MMPs including MMP-1 and MMP-3 is demonstrated in gingival connective tissue of individuals with periodontal...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
), Presenilin 1 (PSEN1), and Presenilin 2 (PSEN2) have been described to cause the early-onset familial form of AD. However, the discovery of genes involved in sporadic late-onset AD has proven to be more difficult. Apolipoprotein-E (APOE) which mediates lipid...
Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
(2005-03-25)
dysfunction in prion diseases. For this purpose I used an immortalized gonadotropin-releasing neuronal cell line (GT1-1) that is susceptible to a mouse-adapted scrapie strain. This cell line represents a suitable system for my studies since the cells possess...