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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Novel non-collagenous modulators of biomineralization in bone and dentin
(2004-11-26)
was the identification and functional analysis of such minor constituents of the ECM in mineralized tissues, bone and dentin.
Our studies on calreticulin (CRT) have demonstrated, for the first time that this Ca 2+binding protein is indeed a component of the ECM...
Studies on fibronectin binding proteins, proteases, and virulence in Staphylococcus aureus
(2004-11-12)
significantly potentiated S. aureus infection in mouse gastrocnemius muscle. Acute muscle damage caused by the myotoxic phospholipase A2 MTIII and ECM degradation by endogenous matrix metalloproteinases (MMP-2 and MMP-9) seemed to be the most important factors...
Staphylococcal cell wall associated proteins : characteristics and host interactions
(2005-11-11)
Staphylococcus aureus and Staphylococcus epidermidis are members of the same family and share several features. S. aureus causes many diseases ranging from mild skin infections to deep tissue infections and septic shock. ...
Prevention and treatment of hepatitis B virus infection
(2005-05-06)
surrogate marker for HBV DNA levels in HBeAg-negative carrier mothers. Of 179 sera analysed, eight (4.5%) tested positive for HBeAg, whereas 171 (95.5 %) were HBeAg-negative. Among the HBeAg-negative mothers, nine had H13V DNA levels predefined as high...
Early detection of Alzheimer's disease and dementia in the general population : results from the Kungsholmen project
(2004-09-08)
, progressed to dementia, and
remained stable or improved. Subjects with CIND had a 3-fold increased
risk of progressing to dementia over 3 years compared to cognitively
intact elderly, and a 2-fold increased risk of death. Individuals who
improved at I' follow...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
-carboxaldehyde and 1,4-diacetyl-2,5-piperazinedione ill the presence of caesium carbonate. Several analogues of dipodazine, together with a few barettin analogues have been prepared and tested for activity ill antifouling assays, results and relevance of which...
The role of the endothelin system in experimental acute lung injury : with special reference to the formation of extra-vascular lung water
(2006-05-12)
Acute lung injury is a major clinical challenge in the intensive care unit. Sepsis is the most frequent underlying cause of this pulmonary syndrome, which contains inflammation-induced diffuse alveolar damage and early ...
Temporal monitoring of intracellular Ca2+ signaling and origins of Ca2+ oscillations
(2006-04-07)
This thesis examined parameters influencing stimulated cytoplasmic free Ca2+ concentration ([Ca2+]i) oscillations in hepatocytes and pancreatic beta-cells. Hepatic glucose output is regulated in part by hormones such as vasopressin that act through...