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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
plaques, where it colocalized with macrophages, endothelial cells, and smooth muscle cells (SMC). Human coronary artery SMC exposed to either the LTB4 Or the BLT1 partial agonist U75302 exhibited increase of whole-cell ion currents indicating...
Molecular basis of estrogen receptor antagonism
(2006-01-27)
Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined ...
Resistance to antiviral drugs in HIV and HBV
(2005-02-18)
Development of resistance to antiviral drugs is a major problem in treatment of several viral infections including human immunodeficiency type 1 (HIV-1) and hepatitis B virus (HBV). Resistance may be the primary reason for ...
Understanding health-related quality of life in old age : a cross-sectional study of elderly people in rural Bangladesh
(2005-11-25)
Background: A rapidly growing subset of the world’s elderly population lives in Bangladesh, where the population aged 60 years and above is projected to almost double in twenty years, from 8.5 million in 2005 to 17.8 million in 2025. The recognition...
Surgical treatment of left main coronary artery stenosis
(2006-04-28)
ventricular function. There was no aortic incompetence. All angioplasties investigated were patent without signs of restenosis or dilatation. The average dimensions of the LMCA after angioplasty were 4.8 mm and 5.6 mm, and in area 18.9 mm 2 and 24.8 MM2...
On gallstone disease : complications and surgical treatment
(2005-11-18)
, with or without CBDS in 24.4%. In the long-term study of LCBDE, 90% of the questionnaires were returned at a mean follow-up of 36 months. Six re-interventions had been performed, but no suspicion of bile duct stricture or mortality related to the prior surgery...
Studies on fat cell function in human obesity and insulin resistance
(2005-09-30)
Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
Catalytic mechanisms and evolution of leukotriene A4 hydrolyse
(2006-11-10)
of chemical mediators, which by different means control, maintain and resolve the process. One group of such mediators is the leukotrienes, among which LTB4 is found. LTB4 has several immunomodulating properties and mainly acts by recruiting leukocytes...