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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Biological aspects of synovial fluid mediated aseptic prosthesis loosening
(2005-08-26)
Aseptic prosthesis loosening is the most common reason for late failure of total hip arthroplasties. Resorption of the peri-prosthetic bone, resulting in a loose prosthesis is characteristic for aseptic loosening. The ...
On gallstone disease : complications and surgical treatment
(2005-11-18)
approaches was assessed. To measure the long-term results of laparoscopic common bile duct exploration (LC13DE), 175 consecutive patients were prospectively registered for a 7-year period beginning in 1992. A retrospective chart review was performed...
Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia
(2006-01-20)
A therapeutic strategy that may potentially delay progression or prevent relapse of B-cell chronic lymphocytic leukemia (B-CLL), is anti-leukemic vaccine therapy. This thesis focuses on comparing different strategies for ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities.
In the first part of this thesis we could establish and confirm ...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
The study of sensory cilia development in Caenorhabditis elegans
(2008-01-04)
Cilia and flagella are widespread eukaryotic subcellular components
that are conserved from green algae to mammals. In different organisms
they function in cell motility, movement of extracellular fluids and
sensory ...
Physical fitness and overweight in Swedish youths
(2005-03-22)
in 10-year-old girls and the lowest (17.5%, 95% CI: 13.6 to 22.2) in 16-year-old girls. The prevalence in 2001 was nearly 2.5 times higher, compared to the 1987-sample. Girls attending schools in smaller towns or on the countryside had a nearly two...
Physical activity, body composition and physical self esteem among children and adolescents
(2005-02-25)
The increasing prevalence of overweight and obesity poses a global health problem. Special concern is focused on overweight during youth since it may cause negative impact on health both during childhood, adolescence and ...