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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Individualized leukapheresis of hematopoietic cells for cellular therapies
(2005-11-24)
Hematopoietic stem and progenitor cells from blood (HSC) are collected by leukapheresis from patients after mobilization with G-CSF +/- chemotherapy to be used in autologous transplantation. The established method to measure ...
Characterization of Eae4 and Eae19-22 in autoimmune neuroinflammation
(2006-02-17)
EAE-QTLs on rat chromosomes 9, 4 and 15 respectively. The DA strain is EAE susceptible both in the MOG- and SC-induced models while the ACI, PVG and BN strains are EAE-resistant. We further bred interval-specific recombinants that allowed us to narrow...
Studies of cellular pathogenesis in experimental autoimmune encephalomyelitis
(2004-08-20)
In this thesis, I have studied antigen-specific therapeutic interventions
of experimental autoimmune encephalomyelitis (EAE) and aimed to
understand the respective roles of different cell subsets in initiation
and ...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Nutritional and functional effects of energy-dense food in the frail elderly
(2004-10-01)
Eating and nutritional problems are common in frail elderly individuals receiving care in municipalities and hospitals. The overall aim of the present thesis was to evaluate the effects of serving additional energy to frail ...
Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients
(2005-04-29)
Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available are not optimal either...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
lies in proximity to an AD linkage peak on chromosome 9q, making ABCA1 both a biological and positional candidate. In four independent European populations, significant differences in genotype frequencies were found between cases and controls indicated...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9...
Modeling individual behavioral changes : the case of tobacco uptake in a cohort of school children
(2005-08-25)
The aim of this thesis was to elucidate preventable determinants of smoking and smokeless tobacco use in adolescence in the frame of a longitudinal study (BROMS cohort). The study population encompasses 3019 children ...