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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
-PSOX, which mediates uptake of oxidized low-density lipoprotein (oxLDL) by cells. We detected abundant CXCL16/SR-PSOX and CXCR6 expression in atherosclerotic lesions from human subjects and apolipoprotein-Edeficient (ApoE-/-) mice. In monocytes, CXCL16/SR...
Giardiasis in Leon, Nicaragua : prevalence and protection
(2006-11-20)
conditions. In a subsequent study a prevalence of 15.6 % of anti-Giardia antibodies in milk was detected in lactating women.
The protective effect of milk anti-Giardia antibodies against G. intestinalis infection was studied in 307 children aged 1 week...
Familial hypercholesterolemia in Sweden : genetic and metabolic studies
(2004-08-27)
Familial hypercholesterolemia (FH) is inherited as an autosomal
codominant disease, usually caused by mutations in the LDL receptor
(LDLR) gene. Heterozygous FH is a common disease with a prevalence of
about 1/500 in ...
Studies on vascular remodeling in acute coronary artery disease
(2005-08-26)
Atherosclerosis is an arterial disease, characterized by endothelial dysfunction, vascular inflammation, and lipid accumulation in the vessel wall. Unstable coronary syndroms may be initiated by rupture of the atherosclerotic ...
Diet and renal cell carcinoma
(2005-01-14)
(multivariate RR = 0.55 (95% Cl, 0.25-1.21 for > 5 servings/day compared to <5-6/week); bananas and root vegetables were significantly inversely associated with RCC risk. Women who drank > 1 servings of alcoholic beverages/week had lower RCC risk than did women...
Socio-demographic determinants of pregnancy outcomes and infant growth in transitional Russia
(2005-02-16)
There is a growing body of literature exploring social, demographic, and life-style factors in relation to pregnancy outcomes and infant growth patterns. However, only a few studies on the topic were conducted in transitional ...
Modulation of nuclear receptor activity by a unique class of corepressors
(2004-09-17)
Nuclear receptors comprise a unique family of transcription factors that are crucial regulators of gene expression involved in diverse physiological and developmental processes. The nuclear receptor field has undergone a ...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Fat mass, adipokines and clinical complications of chronic kidney disease
(2006-05-26)
Patients with chronic kidney disease (CKD), irrespective of initial etiology, have a risk of cardiovascular morbidity (CVD) and mortality that is many-fold higher than that of a similar person without CKD. While traditional ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...