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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Characterisation of psoriasis lesions by protein expression profiling
(2006-05-26)
Psoriasis is a common inflammatory skin disease affecting approximately 2% of the population in Sweden. Psoriasis displays clinical heterogeneity leading to several different types of manifestations, among them chronic ...
The human antimicrobial protein hCAP18/LL37 in wound healing and cell proliferation
(2005-08-26)
Epithelia constitute the principal barriers separating the host and the potentially injurious environment, and defence of this interface is therefore essential. Antimicrobial peptides are key effector molecules of the ...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment
(2005-11-25)
and hamsters. In
terms of sensitivity compared to CYP1A induction (measured as EROD
activity), ED50 values were 0.2, 6.6, 6.5 and 13.7 µg/kg bw, in guinea
pigs, rats, mice and hamsters respectively. In Long-Evans rats, long-term
low-dose TCDD exposure disrupted...
The impact of social security compensation inequality on earnings distribution due to sickness and disability
(2005-08-26)
One of the main purposes of social security systems is to compensate for loss of earnings during periods of sickness and disability. Of interest is therefore the extent to which such compensation reduces earnings inequality. ...
The epidemiology of low back pain in the general population and after motor vehicle collisions : population-based investigations
(2004-11-23)
. There was no evidence of selective
response by LBP status. These subjects were followed at six and 12
months. Prevalence, incidence and course proportions were calculated and
directly standardized to the source population. Paper II is based on a
cohort of 4,124 Swedish...
The functional role of the lateral olivocochlear system and mechanisms underlying sound condtioning
(2004-10-29)
Sound conditioning is a process induced by a low-level, non-damaging acoustic stimulus that provides protection against subsequent detrimental forms of acoustic trauma. Many hypotheses have been advanced to explain the ...
Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease
(2005-01-07)
Alzheimer’s disease (AD) is the most frequent type of dementia and is characterized neuropathologically by deposition of plaques containing beta-amyloid (Abeta) and by neurofibrillary tangles, of which the main component ...
Amino acid and protein turnover in human skeletal muscle
(2005-03-25)
3-3-MH and 2 2H5-phenylalanine, enabled calculation of the rates of appearance for 3-MH and phenylalanine respectively. In the basal state these values were shown to be different from zero during the isotopic steady state. The effects of endotoxin...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein gene product 9.5 (PGP 9.5...