Karolinska Institutet Open Archive
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From autoimmunity to inflamed joints : study of risk factors, mediators and cellular targets in rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-24)Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting mainly the joints and leading to disability. Circulating antibodies against citrullinated proteins (ACPA) are present in the majority of patients and ... -
Impact of childhood leukemia and its treatment on Nordic children and families : the consent process, toxicity, and quality of life
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-04-24)Background: The survival rate in acute lymphoblastic leukemia (ALL) has improved remarkably over the last half-century and is now reaching above 90%. The treatment is lengthy, however, and with a high risk of short- and ... -
Scare or care? How immunological processes shape perception of sickness-relevant stimuli in humans
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-04-23)Humans and other animals have developed several defense systems to handle living in a pathogen-rich world. These defense systems include immune responses, as well as behavioral responses aimed at supporting immune ... -
Primary cilia in human neuron differentiation
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-04-23)Primary (non-motile) cilia have long been overlooked, considered vestigial organelles lacking specific functions. In humans, all cell types except sperm, ependymal and bronchial epithelial cells, and oviduct cells ... -
Risk factors for colorectal cancer and the impact on life in lynch syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-23)Colorectal cancer (CRC) constitutes the third most common cancer in Sweden. Approximately 2-4% of CRC cases have a pathogenic variant in a gene known to cause an inherited risk of CRC. The most common hereditary CRC ...