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Toxicity of smokeless tobacco in human oral epithelium with emphasis on carcinogen metabolism and regulation of programmed cell death
(2002-10-10)
The oral mucosa is globally a common site for cancer development. Primary
risk factors include tobacco smoking and alcohol consumption whereas the
contribution from usage of smokeless tobacco remains debated. The
susceptibility ...
On the role of cytochrome P450 3A4 in the metabolism of cholesterol and bile acids
(2003-12-19)
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The physiological effects of elevated 4beta-hydroxycholesterol levels in humans is as yet unknown. However, previous studies have shown that 4beta-hydroxycholesterol is a relatively potent liver X receptor alpha (LXRalpha) agonist in cell-based transactivation...
Tissue destruction in arthritis : experimental studies
(2003-11-14)
Destruction of joint cartilage and bone is one of the most serious consequences of chronic arthritis. Clinically, the standard assessment of joint destruction is performed by radiography. The sensitivity of radiographic ...
Neuromuscular performance and balance during the menstrual cycle and the influence of premenstrual symptoms
(2004-08-20)
Several studies have demonstrated a higher incidence of sports related knee injuries among female athletes compared to their male counterparts regardless of exposure time and activity level. Different intrinsic and extrinsic ...
Biocomputational studies on protein structures
(2002-08-16)
Biology in the post-genomic era produces large amount of data. This, in combination with the need for efficient algorithms to find genes in the genomic material, has brought a renaissance into the field of computational ...
Vestibular control of body orientation in lamprey
(2004-03-26)
Maintenance of body orientation (postural control) is a vital motor function of the brain. The general goal of this project was to understand the organization and operation of neuronal networks responsible for postural ...
Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment
(2003-10-31)
Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. Renal patients have ...
Intestinal functions in animals : an experimental study on horses, pigs, cows and fish
(2001-11-07)
Animals and humans live in symbiosis with an active gastrointestinal
ecosystem. The balance of the system is maintained by the main actors,
the macroorganism, the microflora and the environment, in concert.
Microflora ...
Perinatal HIV-1 infection : aspects on clinical presentation, viral dynamics and epidemiology
(2004-09-15)
During the last 20 years HIV-1 infection has changed from being an
unknown disease to being a widespread pandemic, in some areas affecting a
large proportion of the human population. Mother-to-child transmission
(MTCT) ...
Particles in small airways : mechanisms for deposition and clearance and pharmacokinetic assessments of delivered dose to the lung
(2004-04-16)
BACKGROUND: Knowledge about lung deposition and clearance from airways of inhaled particles/drugs are essential for evaluation of health effects of inhaled
pollutants and to achieve optimal drug dose to the lung. The ...