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Membrane protein topology : prediction, experimental mapping and genome-wide analysis
(2004-05-12)
Membrane proteins constitute a large and important class of proteins.
They are responsible for many crucial processes in living cells, and
about 25% of all proteins encoded by a typical genome are predicted to be
membrane ...
The treatment of depression in clinical practice : a public health perspective
(2004-05-14)
% an antidepressant. About one-third of the psychotropic drugs were retrieved in post-mortem toxicology. One-quarter of the 4.5% depressed individuals in the population at study were dispensed antidepressant medication, which is a 1.2% prevalence rate for acute...
Molecular consequences of cellular UDP-glucose deficiency
(2004-05-21)
of the transcription factors ATF6 and XBP-1/TREB5, thereby inducing expression of ER chaperones and the transcription factor CHOP/GADD 153. However, a decrease in the cellular levels of UDPG did not induce the expression of CHOP/GADD 153, nor the activation of ATF6...
Regulation of T cell activation and death by the affinity of TCR for peptide/MHC complexes
(2002-05-15)
The aim of this study is to investigate the role of the affinity of peptide:MHC/TCR interaction in the regulation of T cell activation, death and repertoire selection. Three aspects pertinent for our understanding of this ...
Pain following spinal cord injury
(2004-10-01)
The aims of this thesis were to assess and characterise nociceptive and neuropathic pain, the use of pharmacological and non-pharmacological pain treatment, and the influence of pain on the quality of sleep in a population ...
Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution
(2004-05-14)
A striking characteristic of HIV is the enormous capacity of genetic
variation. Frequent mutations, deletions, insertions and recombination
events create a population of genetically related but non-identical
viruses ...
Severe hypoxemia during apnea in humans : influence of cardiovascular responses
(2002-09-13)
When a diving human holds his or her breath, the heart beat slows and the blood vessels constrict in large portions of the body. In diving mammals such as seals, similar responses effectively conserve oxygen for the brain, ...
Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment
(2003-09-05)
GH values, low total IGF-I and in relation to the obesity low levels of free IGF-I and non-suppressed IGF-binding- protein-1 (IGFBP-1). Approximately two thirds were biochemically hypogonadal. Bone mineral density (BMD) was low. Four patients had...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
HC. To investigate if primary BKV infection transmitted from donor to recipient during BMT could cause HC we investigated anti BKV serum titers in BMT recipients and their donors. We also sequenced the non coding control region (NCCR) and the VP1...
Enhancement of HIV-1 DNA immunogens
(2002-11-14)
Human immunodeficiency virus type 1 eludes control by the immune response through a high degree of variability and immune escape mechanisms. Induction of a broad specific immune response is important to clear virus-infected cells. DNA vaccination...