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Regulation of B cell motility and adhesion in health and disease
(2003-11-07)
Migration and adhesion of lymphocytes are crucial to induce an efficient immune response. These activities rely on cytoskeletal dynamics, mediated by assembly of actin and microtubuli monomers leading to changes in cell ...
Effects of perioperative nutrition on insulin action in postoperative metabolism
(2003-04-25)
and immediately after total hip replacement. They were double-blindly treated with either a preoperative carbohydrate-rich beverage (12.5 %, 800+400 ml, n=8) or placebo (n=7). Glucose kinetics (6, 6 D2 D glucose), substrate utilisation (indirect calorimetry...
Functional analysis of genetic variants in putative low penetrate breast cancer genes
(2004-09-03)
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Paper IV: ATM has been suggested to act as a tumour suppression gene that requires the inactivation of both alleles in the development of a malignancy. Two mutations designated as T7271G and IVS1O+6 T-G were reported to increase breast cancer risk...
Parasite signalling and host responses in experimental and human African trypanosomiasis
(2002-08-08)
African trypanosomiasis or sleeping sickness is a disease of tropical Africa caused by the unicellular-flagellated protozoan parasite, Trypanosoma brucei (T b.), which is transmitted by its insect vector, the tsetse fly. ...
Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation
(2002-04-05)
Breast cancer is the most common malignancy among women in the western world. Hormonal treatments for contraception and replacement after menopause have been associated with an increased risk of breast cancer. The basis ...
Exercise and outcome measures in patients with polymyositis and dermatomyositis
(2003-08-22)
Polymyositis (PM) and dermatomyositis (DM) are chronic idiopathic inflammatory myopathies (IIM) which are clinically characterized by symmetrical proximal muscle weakness, fatigue, myalgia and extra- muscular involvement. ...
Endemic ataxic polyneuropathy in Nigeria
(2002-03-22)
of ataxic polyneuropathy in Ososa was 63 per 10 000 personyears, 27 for males and 93 for females. The adjusted odds ratios (95 % CI) were 0.44 (0.09 2.26) for the intake of cassava foods, and 1.74 (0.48- 6.28) for exposure to cyanide. The concentrations...
Minimally invasive hernia surgery
(2003-04-25)
Minimally invasive laparoscopic and open tension-free techniques have been evolved during the 1990's. Different laparoscopic techniques have been used, where the totally extraperitoneal hernioplasty (TEP) is a technically ...
Birth centre care : reproduction and infant health
(2004-04-02)
This thesis has two general aims, to investigate factors affecting
women s decision to have a second baby and to study the effect of birth
centre care on infant outcome. The specific aims were to investigate 1)
whether ...
Studies on antioxidant and lipid lowering effects on human microcirculation
(2002-10-18)
In previous work from this laboratory, vital microscopy was successfully
used to study rnicrocirculatcry effects of hypercholesterolemia in a
rabbit model. Hypercholesterolemia caused a dramatic depression of the
blood ...