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Oxidative stress and calcium signalling : implications for diabetes and cardiac glycosides
(2003-05-23)
The signal transduction processes by which an individual cell is able to recognize and respond to its external environment are critical to determining its survival as well as that of the entire organism. In the current ...
Nuclear compartmentalization of viral and cellular proteins involved in gamma-herpes virus (EBV and HHV-8) mediated cellular transformation
(2003-11-07)
The aim of the work described in this thesis has been to characterize the nuclear compartmentalization of cellular and viral proteins involved in EBV or HHV-8 mediated cellular transformation. We have studied the EBV encoded EBNA-5 and its...
Alexithymia : background and consequences
(2002-03-04)
from 1.8% to 11.7% after the investigation in paper 11. Patients with undetected depression scored higher on alexithymia and psychastenia. In the study in occupational health the prevalence of alexithymia was 7.9% in the all-female population. We found...
Insulin resistance in pancreatic cancer
(2003-05-16)
The dismal prognosis of pancreatic cancer (PC) is related to metabolic complications of the tumor. Impaired glucose tolerance or diabetes due to insulin resistance, and cachexia are observed early and frequently in these ...
A microcell hybrid based elimination test to identify human chromosome 3 regions that antagonize tumor growth
(2003-05-20)
Deletions at multiple sites on the short arm of chr3 have been detected in many different types of human tumors. Each of the deleted regions is expected to harbor a tumor antagonizing/suppressor gene(s) (TSG). The earlier ...
The transcription machinery in schizosaccharomyces pombe and its regulation
(2004-04-28)
Mediator contained 10 subunits conserved in S. cerevisiae and 8 in metazoans. Genetics showed that the conserved subunits were essential for cell growth, whereas the species-specific subunits were non-essential. Our findings led us to propose...
Perinatal HIV-1 infection : aspects on clinical presentation, viral dynamics and epidemiology
(2004-09-15)
During the last 20 years HIV-1 infection has changed from being an
unknown disease to being a widespread pandemic, in some areas affecting a
large proportion of the human population. Mother-to-child transmission
(MTCT) ...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
alleles. IDDM is positively associated with HLA DR3 and DR4 in Caucasians. From HLA-DQ molecules, DQ8 (DQA1*0301- DQB1*0302) is the most prevalent IDDM haplotype in Caucasians, followed by DQ2 (DQA1*0201-DQB1*0501). Taken together, DQ8, DQ2 or both account...
Circulating immune complexes in atherosclerotic vascular disease
(2001-08-31)
We have investigated the association of the humoral immune factors
circulating immune complexes (CICs) and autoantibodies against
cardiolipin (aCL) and oxidatively modified LDL (oxLDL) to atherosclerotic
vascular diseases.
In ...