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Muscarinic M1 and M4 receptor subtypes in normal and pathological conditions in the central nervous system : studies on human and animal tissues using subtype selective ligands
(2003-08-20)
investigated. No M1- toxin 1 binding was observed, indicating an absence of M1 receptors. However, the binding Of M4- toxin 1 was reduced between 87-90 % in the Rexed laminae I to X of the spinal cord both in acute and chronic pain as compared to controls...
The effect of sex hormones on hemostasis and cardiovascular riskfactors in postmenopausal women
(2004-10-29)
The influence of cardiac riskfactors and sex hormones on hemostasis were
studied in healthy women (n=260) in Study I. Body mass Index (BMI),
dyslipidemia, surgical menopause, smoking and years since menopause were
associated ...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...
Neuropeptides and spinal antinociception : studies on galanin, nociceptin and endomorphin
(2003-05-29)
Nociception and/or the sensation of pain is essential for the survival of the organism. Just as important are the antinociceptive mechanisms that reduce the nociceptive input and perceived pain. Without such mechanisms, ...
Cellular immunity and inflammation in atherosclerosis
(2001-11-09)
Atherosclerosis, the major cause of death and disability in western countries, is nowadays recognized as an inflammatory disease. Low density lipoprotein (LDL), the major carrier of cholesterol in plasma, is trapped in the ...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...
Risk characterization of familial cancer using the Swedish family-cancer database with a special reference to breast cancer
(2003-11-07)
This thesis reports on epidemiological studies on family related cancer in Sweden. The Family-Cancer Database was constructed in 1996 from several national registries. Family relations were available from the Generation ...
Studies on antioxidant and lipid lowering effects on human microcirculation
(2002-10-18)
, microvascular reactivity was found to be markedly
reduced. Treatment for 2 weeks with a daily dose of 1g x 3 of vitamin C
did not significantly improve the vascular reactivity. A slight effect
could however be demonstrated in capillary blood flow velocity...
Immunological effects of interferon-beta and glatiramer acetate in multiple sclerosis
(2004-05-06)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in demyelination, axonal loss and neurological deficits. The aetiology is unknown, however, immunopathological events, ...
Perinatal HIV-1 infection : aspects on clinical presentation, viral dynamics and epidemiology
(2004-09-15)
During the last 20 years HIV-1 infection has changed from being an
unknown disease to being a widespread pandemic, in some areas affecting a
large proportion of the human population. Mother-to-child transmission
(MTCT) ...